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Analysis of the functional anatomy involved in the learning of the visual discrimination task in macaque monkeys.

猕猴视觉辨别任务学习中涉及的功能解剖学分析。

基本信息

批准号：
13610105
负责人：
ONOE Hirotaka
金额：
$ 2.11万
依托单位：
Tokyo Metropolitan Organization for Medical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

In monkeys, after the experience of solving hundreds of unique problems of visual discrimination, they become to solve a novel problem very quickly according to the learning-set formation that is defined as learning how to learn the problem. To assess the functional anatomy that is critically involved in learning process of visual discrimination task before and after the learning-set formation, we performed PET study using[^<15>O]-H_2O in monkeys (macaca mulatta).PET images were acquired while monkeys are solving a novel problem of visual discrimination with two geometrical patterns. PET scans were performed at the first experience of the task (an inexperienced novel discrimination, IND), and after the experience of solving several tens of unique problems (an experienced novel discrimination, END). The simple visuomotor task was also conducted as a control.The statistical analysis by SPM revealed that the orbitofrontal, visual, somatosensory, and motor cortices, cerebellum and some subcortical structures were significantly activated in IND, while the dorsolateral prefrontal cortex and visual cortices including higher order areas but not the somatosensory and motor related areas were activated in END.These results indicate that neuronal circuits for the visual discrimination learning dramatically changed depending on their accumulated experience. Recruitments of dorsolateral prefrontal cortex and higher order visual areas could be associated with the learning-set formation for the visual discrimination learning in monkeys.

对于猴子来说，在经历了解决数百个独特的视觉辨别问题之后，它们能够根据学习集的形成（定义为学习如何学习问题）很快地解决新问题。为了评估在学习集形成之前和之后视觉辨别任务的学习过程中至关重要的功能解剖学，我们使用[^<15>O]-H_2O在猴子（猕猴）中进行了PET研究。PET图像是在猴子解决具有两种几何图案的视觉辨别新问题时获取的。 PET 扫描是在第一次执行任务时（一次新奇判别，IND）以及解决数十个独特问题后（一次新判别，END）进行的。还进行了简单的视觉运动任务作为对照。SPM的统计分析显示，IND中眶额皮质、视觉皮质、体感皮质和运动皮质、小脑和一些皮质下结构在IND中显着激活，而背外侧前额皮质和视觉皮质（包括高阶区域）在END中被激活，但体感和运动相关区域没有被激活。这些结果表明，视觉辨别学习的神经回路根据他们积累的经验而发生巨大变化。背外侧前额叶皮层和高阶视觉区域的募集可能与猴子视觉辨别学习的学习集形成相关。