Neuronal and biological bases of the motivation in rehabilitation

在这里，我们显示腹侧纹状体，包括伏隔核(NAC)，在动机加工中起关键作用的活动增加，其与M1的功能连接出现，并在恢复过程中逐渐加强。此外，在恢复过程中，M1、腹侧纹状体和其他属于加工动机神经回路的结构之间的功能联系也得到了加强。此外，在脊髓损伤前用鹅膏糖酸损毁NAC会导致恢复的延迟。这些结果为脊髓损伤后功能恢复所需的运动学习动机调节的神经元底物提供了线索。

Here, we show that activity of the ventral striatum, including the nucleus accumbens(NAc), which plays a critical role in processing of motivation, increased and its functional connectivity with M1 emerged and was progressively strengthened during the recovery. In addition, functional connectivities among M1, the ventral striatum and other structures belonging to neural circuits for processing motivation were also strengthened during the recovery. In addition, lesion of NAc by ibotenic acid prior to spinal cord injury resulted in the delay of recovery. These results give clues to the neuronal substrate for motivational regulation of motor learning required for functional recovery after spinal-cord injury.