Fabrication of Self-Assembled Monolayers with Dyes and Saccharides as Receptors for Viruses

用染料和糖作为病毒受体的自组装单分子层的制备

• 批准号: 13650032
• 负责人: OKAWA Haruki
• 金额: $ 2.24万
• 依托单位: Kogakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650032/
• 关键词: a Self-Assembled Monolayer; Alkanethiol Derivatives; Surface Plasmon Resonance; Hemicyanine; Second harmonic Generation; Glucose; 細胞膜; 色素配向; 自己組織化単分子膜膜; XPS; ポリチオフェン; 細菌吸着; 表面プラズモン; ブリュースター角顕微鏡; J会合体; アルカンチオール

For modeling cell walls and viruses, we have been tried to fabricating self-assembled monolayers (SAM) including dyes as indicators and saccharides as receptor for viruses. At first, substituted long alkanethiol derivatives including hemicyanine dyes, 11,11'-dithio-di[1-unfrvyl-4'-4''-dimethylaminostyryl)pyridinium bromide] (DMHA) and 11,11'-dithio-di[1-undecyl-4'-(4''-dimethylaminostyryl)pyridinium bromide] (DBHA) were synthesized. Using these alkanthiols, we tried to deposit organic thin films on gold surfaces. The structures of the films were characterized by the surface plasmon resonance measurement. Comparing the resonance in the self-assembled monolayer of octadecane thiol it was found that the dye molecules were adsorbed on the gold surfaces and formed self-assembled monolayers. The time dependence of the resonance show that the DMHA molecules were adsorbed on the SAM of DMHA differently from the DBHA molecules. The difference can be explained by the steric hindrance of alkyl substitutents on end amino groups (methyl or butyl). These groups existed on the surfaces of the SAM and affected on the structure of the surfaces.

为了建模细胞壁和病毒，我们已经尝试制造自组装的单层（SAM），包括染料作为指示剂和糖水作为病毒的受体。首先，取代的长烷硫醇衍生物，包括半蛋白染料，11,11'-Dithio-Di [1- unfryl-4'-4'-4''' - 二甲基氨基氨基酯）吡啶二氨基二酰胺]（DMHA）（DMHA）和11,11,11'-Dithio-dithio-di [1- dithio-di [1- undecyl-4' - （4''''''''''' - ''''''''''' - ''''''''''''' - （DBHA）合成。使用这些烷硫醇，我们试图将有机薄膜沉积在金表面上。膜的结构以表面等离子体共振测量为特征。比较八烷基硫醇的自组装单层中的共振，发现染料分子被吸附在金表面上并形成自组装的单层。共振的时间依赖性表明，DMHA分子与DMHA的SAM与DBHA分子不同。差异可以通过烷基替代物在末端氨基（甲基或丁基）上的空间障碍来解释。这些组存在于SAM的表面上，并在表面的结构上受到影响。

项目成果

Naraoka, Ryo, Kaise, Go, Kajikawa, Kotaro, Okawa, Haruki, Ikezawa, Hiroki, Hashimoto: "Nonlinear optical property of hemicyanine self-assembled monolayers on gold and its adsorption kinetics probed by optical second-harmonic generation and surface plasmon

Naraoka、Ryo、Kaise、Go、Kajikawa、Kotaro、Okawa、Haruki、Ikezawa、Hiroki、Hashimoto：“金上半花青自组装单层的非线性光学特性及其通过光学二次谐波产生和表面等离子体探测的吸附动力学

Okawa Haruki, Ikezawa Hiroki, Hashimoto, Kazuhiko: "Synthesis and characterization of an alkanthiol thin film containing a hemicyanine dye"Molecular Crystals and Liquid Crystals Science & Thechnology, Section A. 377. 137-140 (2002)

Okawa Haruki、Ikezawa Hiroki、Hashimoto、Kazuhiko：“含有半花青染料的链烷硫醇薄膜的合成和表征”分子晶体与液晶科学

Okawa, Haruki, Ikezawa, Hiroki, Hashimoto, Kazuhiko: "Synthesis and characterization of an alkanethiol thin film containing a hemicyanine dye"MCLC S&T, Section A : Molecular Crystals and Liquid Crystals. 377. 137-140 (2002)

Okawa、Haruki、Ikezawa、Hiroki、Hashimoto、Kazuhiko：“含有半花青染料的烷硫醇薄膜的合成和表征”MCLC S

Okawa Haruki, Ikezawa Hiroki, Hashimoto Kazuhiko: "Synthesis and characterization of an alkanthiol thin film containing a hemicyanine dye"Molecular Crystals and Liquid Crystals Section A. 377. 137-140 (2002)

Okawa Haruki、Ikezawa Hiroki、Hashimoto Kazuhiko：“含有半花青染料的烷硫醇薄膜的合成和表征”分子晶体和液晶部分 A. 377. 137-140 (2002)

Okawa, Haruki, Ikezawa, Hiroki, Hashimoto, Kazuhiko.: "Synthesis and characterization of an alkanethiol thin film containing a hemicyanine dye."Molecular Crystals and Liquid Crystals Science and Technology, Section A : Molecular Crystals and Liquid Crysta

Okawa、Haruki、Ikezawa、Hiroki、Hashimoto、Kazuhiko.：“含有半花青染料的烷硫醇薄膜的合成和表征。”分子晶体和液晶科学与技术，A 部分：分子晶体和液晶