The role of a previously unrecognised E3 ligase in regulating TLR3 signalling (A12*)

以前未被识别的 E3 连接酶在调节 TLR3 信号传导中的作用 (A12*)

• 批准号: 531875680
• 金额: --
• 依托单位: Institut für Biochemie I
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/531875680?language=en
• 关键词: role; previously; unrecognised; E3; ligase

The Walczak group recently found that upon TLR3 stimulation, different from TNFR1 signalling and despite LUBAC also forming part of the TLR3 signaling complex, TBK1 activation is independent from LUBAC. Parting therefrom, another E3 ligase was now identified as required for TBK1 activation following TLR3 stimulation. During the next funding period, the role of this enzyme in the regulation of TLR3 signaling will be characterized in vitro and in vivo.

Walczak小组最近发现，在TLR3刺激时，与TNFR1信号传导不同，尽管LUBAC也形成TLR3信号传导复合物的一部分，但TBK1活化独立于LUBAC。与之分开，现在鉴定出另一种E3连接酶是TLR3刺激后TBK1活化所需的。在下一个资助期间，这种酶在调节TLR3信号传导中的作用将在体外和体内进行表征。