Glycal approaches to the synthesis of biologically active compounds

合成生物活性化合物的糖基方法

• 批准号: 5319034
• 负责人: Dr. Hans-Georg Weinig
• 金额: --
• 依托单位: Gesellschaft Deutscher Chemiker e.V. (GDCh)
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2001
• 资助国家: 德国
• 起止时间: 2000-12-31 至 2001-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5319034?language=en
• 关键词: Glycal; approaches; synthesis; biologically; active

The project will be focused on the enantioselective solid-supported synthesis of natural and unnatural deoxy-azasugars and lactams starting from different glycals. The first goal ist the development of new and efficient strategies for chemoselective protection and deprotection sequences for the hydroxyl groups in the polymer-bound starting materials. Following these strategies, a variety of new compounds will be prepared starting from different glycals. Solidphase synthesis and examination of the biological activity, especially glycosidase inhibition properties, of all the new compounds represent the long term goal of the described project.

该项目将侧重于从不同的糖基化合物出发，对映选择性地固相合成天然和非天然脱氧氮杂糖和内酰胺。第一个目标是开发新的和有效的策略，用于聚合物结合的起始材料中的羟基的化学选择性保护和去保护序列。根据这些策略，将从不同的糖基开始制备各种新化合物。所有新化合物的固相合成和生物活性，特别是糖苷酶抑制性质的检测代表了所述项目的长期目标。