Glycal approaches to the synthesis of biologically active compounds

该项目将侧重于从不同的糖基化合物出发，对映选择性地固相合成天然和非天然脱氧氮杂糖和内酰胺。第一个目标是开发新的和有效的策略，用于聚合物结合的起始材料中的羟基的化学选择性保护和去保护序列。根据这些策略，将从不同的糖基开始制备各种新化合物。所有新化合物的固相合成和生物活性，特别是糖苷酶抑制性质的检测代表了所述项目的长期目标。

The project will be focused on the enantioselective solid-supported synthesis of natural and unnatural deoxy-azasugars and lactams starting from different glycals. The first goal ist the development of new and efficient strategies for chemoselective protection and deprotection sequences for the hydroxyl groups in the polymer-bound starting materials. Following these strategies, a variety of new compounds will be prepared starting from different glycals. Solidphase synthesis and examination of the biological activity, especially glycosidase inhibition properties, of all the new compounds represent the long term goal of the described project.