Exploiting XtalFluor reagents in organic synthesis and developing new approaches to pentafluorosulfanyl-containing molecules

在有机合成中利用 XtalFluor 试剂并开发含五氟硫基分子的新方法

• 批准号: 572205-2022
• 负责人: Paquin, JeanFrançoisJF
• 金额: $ 3.72万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748629
• 关键词: Exploiting; XtalFluor; reagents; organic; synthesis

The projects described herein aim at the development of new synthetic tools for the preparation of organic compounds, in particular fluorine-containing molecules which are of high interest in pharmaceutical industry, in agrochemistry as well as in material sciences. Specific objectives are: 1) the improvement of the deoxofluorination reaction using OmegaChem's XtalFluor reagents; 2) the discovery of new transformations using OmegaChem's XtalFluor reagents for the synthesis of fluorinated (sulfonyl fluorides) and non-fluorinated compounds (acyl halides); and 3) the development of novel synthetic approaches to pentafluorosulfanyl-containing compounds. Overall, these projects are significant in the context that OmegaChem is continually working to introduce on the market new molecules that can be integrated to the design of more complex structures demonstrating innovative properties and increased efficiency.

本文描述的项目旨在开发新的合成工具来制备有机化合物，特别是在制药工业、农业化学和材料科学中高度感兴趣的含氟分子。具体目标是：1)使用OmegaChem的XtalFluor试剂改进脱氧氟化反应；2)发现使用OmegaChem的XtalFluor试剂合成氟化物(磺酰氟化物)和非氟化物(酰卤化物)的新转化；以及3)开发含五氟磺基化合物的新合成方法。总体而言，这些项目在欧米茄化学公司不断努力向市场推出新分子的背景下具有重要意义，这些新分子可以集成到更复杂的结构设计中，展示出创新的特性和更高的效率。