The effect of physical activity on bone mineral density in severely disabled persons

测定身体和精神残疾患者的骨密度（BMD），了解性别、年龄、身体残疾程度、抗癫痫药物、维生素D3、钙等因素是否对骨密度或骨折有不良影响。采用计算机x射线密度法（CXD）测量骨密度。选择了80名受试者（男性40名，女性40名），对48名受试者进行了身体活动测量。根据大岛标准对身体残疾程度进行分类。作者将以下四个阶段分为1到4个阶段；躺在床上，可以坐着，不能走路但可以自己移动，可以走路。此外，活动监测设备，名为ACTIWATCH^<〇！>，被安装在他们隐性手臂的手腕上。采样频率为32 Hz，灵敏度为0.01 G，以1分钟为单位计数。身体运动的次数是通过有功电量的总和来计算的。如果计数的次数平均每分钟达到100,000或更高，则作者判断为“活跃”。各组分别为39例、21例、8例、12例。平均年龄男性30.7±12.6岁，女性35.7±14.6岁。采用多元logistic回归分析预测是否存在骨无力（以BMD% < 80表示）或骨折。年龄、丙戊酸盐的使用和骨密度被认为是骨折的重要危险因素。

Bone mineral densities (BMD) of physically and mentally disabled patients were measured to know whether some factors such as sex, age, physical disability level, anti-epileptic drug, vitamin D3, calcium have adverse effect on BMD or bone fracture. BMD was measured by Computed X-Ray Densitometry (CXD) method. Eighty subjects (40 in male and 40 in female) were selected and physical activity was measured on 48 subjects. Physical disability level was classified according to the Oshima criteria. The authors numbered the following four stages as 1 to 4; lying in bed, can keep sitting, cannot walk but can move by him / herself, can walk. In addition, the activity-monitoring device, named ACTIWATCH^<【○!R】>, was installed on the wrist of their recessive arms. The sampling frequency was 32 Hz and sensitivity was 0.01 G, counting for one minute as a unit. The number of body movement was calculated by the summation in the number of active electricity. If the number of count becomes 100,000 or higher per minute on average, the author judged "active". Each group contains 39,21,8,12 patients, respectively. The average age was 30.7±12.6 in male and 35.7±14.6 in female. Multiple logistic regression analysis was applied to predict the existence of bone weakness, which is expressed as BMD% under 80, or bone fracture. Aging, medication of valproate, and BMD were selected as significant risk factors for bone fracture.