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The effect of physical activity on bone mineral density in severely disabled persons

体力活动对严重残疾人骨密度的影响

基本信息

批准号：
13670354
负责人：
KAWADA Tomoyuki
金额：
$ 1.98万
依托单位：
Nippon Medical School (2003)Gunma University (2001-2002)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

Bone mineral densities (BMD) of physically and mentally disabled patients were measured to know whether some factors such as sex, age, physical disability level, anti-epileptic drug, vitamin D3, calcium have adverse effect on BMD or bone fracture. BMD was measured by Computed X-Ray Densitometry (CXD) method. Eighty subjects (40 in male and 40 in female) were selected and physical activity was measured on 48 subjects. Physical disability level was classified according to the Oshima criteria. The authors numbered the following four stages as 1 to 4; lying in bed, can keep sitting, cannot walk but can move by him / herself, can walk. In addition, the activity-monitoring device, named ACTIWATCH^<【○!R】>, was installed on the wrist of their recessive arms. The sampling frequency was 32 Hz and sensitivity was 0.01 G, counting for one minute as a unit. The number of body movement was calculated by the summation in the number of active electricity. If the number of count becomes 100,000 or higher per minute on average, the author judged "active". Each group contains 39,21,8,12 patients, respectively. The average age was 30.7±12.6 in male and 35.7±14.6 in female. Multiple logistic regression analysis was applied to predict the existence of bone weakness, which is expressed as BMD% under 80, or bone fracture. Aging, medication of valproate, and BMD were selected as significant risk factors for bone fracture.

通过测定肢体残疾和智力残疾患者的骨密度（BMD），了解性别、年龄、肢体残疾程度、抗癫痫药物、维生素D3、钙等因素是否对BMD或骨折有不良影响。骨密度测定采用计算机X线密度测定法（CXD）。选择了80名受试者（男性40名，女性40名），并对48名受试者进行了体力活动测量。根据Oshima标准对肢体残疾程度进行分级。作者将以下4个阶段编号为1 - 4;躺在床上，可以保持坐着，不能行走但可以自己移动，可以行走。此外，名为ACTIWATCH^<[○！R]>，被安装在他们隐性手臂的手腕上。采样频率为32 Hz，灵敏度为0.01 G，以1分钟为单位计数。身体运动的次数由有功电的次数之和计算。如果计数的数量平均每分钟达到100，000或更高，则作者判断为“活跃”。两组分别为39例、21例、8例、12例。平均年龄男性30.7±12.6岁，女性35.7±14.6岁。应用多元Logistic回归分析预测骨密度%<80的骨质疏松或骨折的存在。年龄、丙戊酸盐用药和BMD被选为骨折的显著风险因素。