A population-based case-control study of pancreatic cancer

基于人群的胰腺癌病例对照研究

• 批准号: 13670358
• 负责人: TAMAKOSHI Akiko
• 金额: $ 2.11万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670358/
• 关键词: Pancreatic cancer; case-control study; risk factors; smoking

We conducted a population-based case-control study to evaluate the risk of pancreatic cancer in relation to lifestyle factors such as cigarette smoking, alcohol and coffee consumption and nutrient intake. Cases were 109 patients who were newly diagnosed with pancreatic cancer between January 2000 and April 2002. Control subjects were 218 persons who were randomly selected from the electoral register and were matched for cases on sex, age and residence. The data on lifestyle factors were collected by in-person interview with cases and controls. Conditional logistic model was used to calculate the odds ratios and their 95% confidence intervals. The odds ratios were adjusted for cumulative amount of cigarette smoking and history of diabetes. Our study confirmed that cigarette smoking was associated with an increased risk of pancreatic cancer, with the odd ratios being 2.3 for current smokers. Alcohol and coffee consumption were not associated with risk of pancreatic cancer. An increased risk was observed among those who had a history of diabetes (OR=2.4). The weight loss more than 5 kg within five years before the diagnosis was associated with an increased risk; Subjects in the highest tertile of cholesterol intake had 2-fold significantly increased risk than those in the lowest tertile. Higher vitamin C intake significantly decreased the risk. Our study suggested that alexithymia may increase the risk of pancreatic cancer.

我们进行了一项基于人群的病例对照研究，以评估与吸烟、饮酒和咖啡消费以及营养摄入等生活方式因素相关的胰腺癌风险。病例为2000年1月至2002年4月期间新诊断出胰腺癌的109名患者。对照对象为从选民登记册中随机抽取的218人，并在性别、年龄和居住地方面进行匹配。有关生活方式因素的数据是通过对病例和对照进行面对面访谈来收集的。使用条件逻辑模型来计算比值比及其 95% 置信区间。根据累积吸烟量和糖尿病史调整优势比。我们的研究证实，吸烟与胰腺癌风险增加相关，当前吸烟者的奇数比为 2.3。酒精和咖啡的摄入与胰腺癌的风险无关。有糖尿病史的人的风险增加（OR=2.4）。诊断前五年内体重减轻超过5公斤与风险增加相关；胆固醇摄入量最高三分位数的受试者的风险比最低三分位数的受试者显着增加 2 倍。较高的维生素 C 摄入量可显着降低风险。我们的研究表明述情障碍可能会增加患胰腺癌的风险。