The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis

血清可溶性CD163水平反映类风湿关节炎的活动性。此外，活动性肝炎患者血清可溶性CD163水平升高。可溶性CD163的脱落受到金属蛋白酶3组织抑制剂的抑制。这一发现提示ADAM家族蛋白酶可能参与了膜质CD163的裂解。如先前报道的那样，接触珠蛋白和血红蛋白的复合物与可溶性CD163结合。此外，我们发现单独的血红蛋白可以与可溶性CD163结合。

The serum levels of soluble CD163 reflected the activity of rheumatoid arthritis. Additionally, the serum levels of soluble CD163 were elevated in active hepatitis. The shedding of soluble CD163 was inhibited by tissue inhibitor of metalloproteinase 3. This finding suggests that ADAM family proteinase might be involved in the cleavage of membranous CD163.The complex of haptoglobin and hemoglobin was bound to soluble CD163 as previously reported. Additionally, we found that hemoglobin alone could bind to soluble CD163.