The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis

可溶性CD163在类风湿性关节炎中的诊断及病理意义

• 批准号: 13670464
• 负责人: MATSUYAMA Takami
• 金额: $ 2.3万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670464/
• 关键词: soluble CD163; rheumatoid arthritis; hemoglobin; hepatitis; 色素沈着絨毛性滑膜炎; CD163; 可溶性; 慢性関節リウマチ; TIMP

The serum levels of soluble CD163 reflected the activity of rheumatoid arthritis. Additionally, the serum levels of soluble CD163 were elevated in active hepatitis. The shedding of soluble CD163 was inhibited by tissue inhibitor of metalloproteinase 3. This finding suggests that ADAM family proteinase might be involved in the cleavage of membranous CD163.The complex of haptoglobin and hemoglobin was bound to soluble CD163 as previously reported. Additionally, we found that hemoglobin alone could bind to soluble CD163.

血清可溶性CD163水平反映了类风湿关节炎的活动性。此外，活动期肝炎患者血清可溶性CD163水平升高。金属蛋白酶组织抑制物3抑制了可溶性CD163的脱落，提示ADAM家族的蛋白酶可能参与了膜CD163的裂解。结合珠蛋白和血红蛋白的复合体与可溶性CD163的结合与文献报道一致。此外，我们发现单独的血红蛋白可以与可溶性CD163结合。

项目成果

Matsushita N, Matsuyama T 他: "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol. 130(1). 156-161 (2002)

Matsushita N、Matsuyama T 等人：“类风湿性关节炎患者血清和体液中可溶性 CD163 水平升高以及 TIMP-3 对 CD163 脱落的抑制”Clin Exp Nutrition 130(1)。 ）

Matsushita N, Matsuyama T 他: "Elevated levels of soluble CD 163 in sera and fluids from rheumatoid Arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol.. 130(1). 156-161 (2002)

Matsushita N、Matsuyama T 等人：“类风湿关节炎患者血清和体液中可溶性 CD 163 水平升高以及 TIMP-3 对 CD163 脱落的抑制”Clin Exp Immunol.. 130(1)。 (2002)

Ijiri K, Matsuyama T 他: "Differential expression patterns of secreted frizzled related protein genes in synovial cells from patients with arthritis"J. Rheumatology. 29. 2266-2270 (2002)

Ijiri K、Matsuyama T 等人：“关节炎患者滑膜细胞中分泌的卷曲相关蛋白基因的差异表达模式”J.Rheumatology 29. 2266-2270 (2002)

Matsushita N, Matsuyama T et al.: "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol. 130(1). 156-161 (2002)

Matsushita N、Matsuyama T 等人：“类风湿关节炎患者血清和体液中可溶性 CD163 水平升高以及 TIMP-3 对 CD163 脱落的抑制”

Nakamura M, Matsuyama T 他: "Nitration and chlorination of folic acid by peroxynitrite and hypochloric acid, and the selective binding of 10-nitro-folate to folate receptor β"Biochem. Biophys.Res.Commun.. 297. 1238-1244 (2002)

Nakamura M、Matsuyama T 等人：“过氧亚硝酸盐和次氯酸对叶酸的硝化和氯化，以及 10-硝基叶酸与叶酸受体 β 的选择性结合”Biochem.Biophys.Res.Commun. 297. 1238 -1244（2002）