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The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis

The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritis
可溶性CD163在类风湿性关节炎中的诊断及病理意义
批准号:
13670464
负责人:
MATSUYAMA Takami
金额:
$2.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002

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英文摘要
The serum levels of soluble CD163 reflected the activity of rheumatoid arthritis. Additionally, the serum levels of soluble CD163 were elevated in active hepatitis. The shedding of soluble CD163 was inhibited by tissue inhibitor of metalloproteinase 3. This finding suggests that ADAM family proteinase might be involved in the cleavage of membranous CD163.The complex of haptoglobin and hemoglobin was bound to soluble CD163 as previously reported. Additionally, we found that hemoglobin alone could bind to soluble CD163.
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Matsushita N, Matsuyama T 他: "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol. 130(1). 156-161 (2002)
Matsushita N、Matsuyama T 等人:“类风湿性关节炎患者血清和体液中可溶性 CD163 水平升高以及 TIMP-3 对 CD163 脱落的抑制”Clin Exp Nutrition 130(1)。 )
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Matsushita N, Matsuyama T 他: "Elevated levels of soluble CD 163 in sera and fluids from rheumatoid Arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol.. 130(1). 156-161 (2002)
Matsushita N、Matsuyama T 等人:“类风湿关节炎患者血清和体液中可溶性 CD 163 水平升高以及 TIMP-3 对 CD163 脱落的抑制”Clin Exp Immunol.. 130(1)。 (2002)
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Ijiri K, Matsuyama T 他: "Differential expression patterns of secreted frizzled related protein genes in synovial cells from patients with arthritis"J. Rheumatology. 29. 2266-2270 (2002)
Ijiri K、Matsuyama T 等人:“关节炎患者滑膜细胞中分泌的卷曲相关蛋白基因的差异表达模式”J.Rheumatology 29. 2266-2270 (2002)
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Matsushita N, Matsuyama T et al.: "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3"Clin Exp Immunol. 130(1). 156-161 (2002)
Matsushita N、Matsuyama T 等人:“类风湿关节炎患者血清和体液中可溶性 CD163 水平升高以及 TIMP-3 对 CD163 脱落的抑制”
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Therapy targeting folate receptor beta expressing macrophages in chronic inflammation
  • 批准号:
    23591441
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.49万
  • 财政年份:
    2011
  • 负责人:
    MATSUYAMA Takami
  • 依托单位:
A preclinical study using recombinant anti-folate receptor-beta immunotoxin for the treatment of rheumatoid arthritis
  • 批准号:
    17591051
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.37万
  • 财政年份:
    2005
  • 负责人:
    MATSUYAMA Takami
  • 依托单位:
Inhibitory effects of membraneous beparin binding EGF like Factor on the apoptosis.
  • 批准号:
    11670453
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.54万
  • 财政年份:
    1999
  • 负责人:
    MATSUYAMA Takami
  • 依托单位:
Mechanisms of the anergy of T cells induced by varient types of soluble VCAM-1
  • 批准号:
    09670483
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.73万
  • 财政年份:
    1997
  • 负责人:
    MATSUYAMA Takami
  • 依托单位:
国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data