Bronchila asthma and new Th2 type gene-ST2

人ST2基因可在成纤维细胞中被生长刺激特异性诱导，ST2蛋白在辅助性T细胞2型（Th2）细胞中优先表达。(1)哮喘中可溶性ST2蛋白水平我们对特应性哮喘患者进行检查，发现哮喘急性加重患者血清ST2水平明显升高。这种增加与哮喘恶化的严重程度密切相关。(2)动物模型1)LPS、il - 1β、IL-6和TNF α诱导小鼠肺泡巨噬细胞系MH-S细胞ST2 mRNA表达。ST2蛋白预处理可减少这类促炎细胞因子的蛋白生成。2)我们的小鼠模型提示，过敏原暴露后内源性mST2蛋白的增加可能调节th2介导的气道炎症，并且体内mST2基因转移可适用于用于过敏性疾病的新型免疫治疗。(3)Th1/Th2失衡与肺纤维化特发性肺纤维化（IPF）稳定状态下血清ST2水平与健康对照组无明显差异，而急性肺纤维化组血清ST2水平明显高于稳定或健康对照组。

The human ST2 gene can be specifically induced by growth stimulation in fibroblastic cells, and ST2 protein is expressed preferentially in helper T cell type-2 (Th2) cells.(1)Soluble ST2 protein levels in AsthmaWe examined patients with atopic asthma and found a significant increase of serum ST2 level in the patients **h asthma with an acute exacerbation. This increase correlates well with the severity of asthma exacerbation.(2)Animal models1)LPS, IL1β, IL-6 and TNF αinduced ST2 mRNA expression in a murine alveolar macrophage cell line, MH-S cells. And pretreatment with ST2 protein reduced the protein production of such pro-inflammatory cytokines.2)Our murine models suggest that increases in endogenous mST2 protein after allergen exposure may modulate Th2-mediated airway inflammation, and that in vivo gene transfer of mST2 can be applicable to use in a novel immunotherapy for allergic diseases.(3)Th1/Th2 imbalance and pulmonary fibrosisThe serum levels of ST2 of idiopathic pulmonary fibrosis (IPF) in the stable state did not differ from those in the healthy control group, while the serum levels of ST2 of IPF in the acute exace bation group were significantly higher than those of stable or healthy control group.