Hemodynamically independent analysis of intracranial cerebrospinal fluid dynamics using PC cine MRI

使用 PC 电影 MRI 对颅内脑脊液动力学进行血流动力学独立分析

• 批准号: 13670923
• 负责人: MIYATI Tosiaki
• 金额: $ 1.98万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670923/
• 关键词: Magnetic resonance image : MRI; Frequency analysis; Normal pressure hydrocephalus; Cine MRI; Phase contrast; Phase transfer function; Compliance; Cerebrospinal fluid dynamics

To clarify intracranial dynamical properties in normal pressure hydrocephalus (NPH), we assessed a spectral phase transfer function (PTF) calculated from the driving vascular pulsation and cerebrospinal fluid (CSF) flow in the aqueduct using phase contrast (PC) cine MRI.On a vertical plane against a mid-point on the long axis of the aqueduct, both CSF flow and blood flow waveforms were measured with cardiac triggered PC cine MRI. Taking the difference in each cardiac phase between arterial inflow and venous outflow in the brain as the input function (driving vascular pulsation), and the CSF flow in the aqueduct as the output function, the PTF related to the dynamical properties was calculated from both functions. The PTF was determined in patients with NPH after a subarachnoid hemorrhage (SAH-NPH), in an SAH-NPH post-shunt operation group, and in healthy volunteers (control group). The PTF(f)s were also measured 5 min after an intravenous injection of acetazolamide (increase of cerebral blood volume). The PTF was compared with the pressure volume response (PVR) as an index of the intracranial compliance.The PTF of the 1st harmonic in the SAH-NPH group was significantly larger than in the control group, and the PTF in the SAH-NPH post-shunt operation group tends to be closer to that in the control group than the SAH-NPH group. There was no significant difference in PTF before and after acetazolamide injection at any frequency ; independent of hemodynamics. A positive correlation was noted between the PTFPTF analysis with PC cine MRI makes it possible to obtain information noninvasively on intracranial dynamical properties in cases of NPH.

为了阐明正常压力性脑积水(NPH)的颅内动力学特征，我们利用相位对比(PC)电影磁共振成像技术计算了导水管内驱动血管搏动和脑脊液(CSF)流动的频谱相转移函数(PTF)。在与导水管长轴中点垂直的平面上，用心脏触发PC电影MRI测量了脑脊液流量和血流波形。以脑内动脉流入和静脉流出时相的差值为输入函数(驱动血管搏动)，以导水管内脑脊液流量为输出函数，由这两个函数计算出与动力学特性相关的PTF。测定蛛网膜下腔出血后出血患者(SAH-NPH)、SAH-NPH分流术后组和健康志愿者(对照组)的PTF。在静脉注射乙酰唑胺5分钟后测定S的PTF(F)(增加脑血容量)。SAH-NPH组一次谐波的PTF明显大于对照组，分流术后组PTF较SAH-NPH组更接近对照组。在任何频率注射乙酰唑胺前后，PTF均无显著差异；与血流动力学无关。PTFPTF分析与PC电影MRI呈正相关，这使得无创性地获得NPH病例的颅内动力学特性信息成为可能。

项目成果

宮地利明, 藤田広志, 間瀬光人, 春日敏夫, 今井広, 市川勝弘: "正常圧水頭症のcine MRIにおける髄液流量波形の周波数解析"医用電子と生体工学. 39(3). 203-212 (2001)

Toshiaki Miyaji、Hiroshi Fujita、Mitsuto Mase、Toshio Kasuga、Hiroshi Imai、Katsuhiro Ichikawa：“正常压力脑积水的电影 MRI 中脑脊液流动波形的频率分析”医学电子与生物工程 39(3)。

Mitsuhito Mase, Tosiaki Miyati, et al.: "CSF flow dynamics in patients with normal pressure hydrocephalus/ frequency analysis using cine-MRI"Progress in Research on Brain Edema and ICP [2002]. 41-49 (2002)

Mitsuhito Mase、Tosiaki Miyati 等人：“正常压力脑积水患者的 CSF 流动动力学/使用电影 MRI 进行频率分析”脑水肿和 ICP 研究进展 [2002]。

間瀬光人, 宮地利明, 他: "正常圧水頭症患者のMRIによる髄液循環動態の周波数解析"Progress in Research on Brain Edema and ICP[2002]. 41-49 (2002)

Mitsuto Mase、Toshiaki Miyaji 等：“使用 MRI 对正常压力脑积水患者脑脊液血流动力学进行频率分析”脑水肿和 ICP 研究进展[2002] 41-49 (2002)。

Tosiaki Miyati, et al.: "Spectral PTF analysis using cine-MRI in normal pressure hydrocephalus"CARS 2002 Proceedings. 1047-1047 (2002)

Tosiaki Miyati 等人：“在常压脑积水中使用电影 MRI 进行光谱 PTF 分析”CARS 2002 论文集。

間瀬光人, 宮地利明, 他: "正常圧水頭症患者のMRIによる髄液循環動態の周波数解析"Progress in Research on Brain Edema and ICP [2000]. 41-49 (2002)

Mitsuto Mase、Toshiaki Miyaji 等人：“使用 MRI 对正常压力脑积水患者的脑脊液血流动力学进行频率分析”脑水肿和 ICP 的研究进展 [2000] 41-49 (2002)。