Quantitative analysis of intracranial compliance using MRI

使用 MRI 定量分析颅内顺应性

• 批准号: 15591261
• 负责人: MIYATI Tosiaki
• 金额: $ 2.24万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591261/
• 关键词: Magnetic resonance image : MRI; Normal pressure hydrocephalus; Cine MRI; Phase contrast; Compliance; Cerebrospinai fluid dynamics; Pressure gradient; Volume-pressure response; エラスタンス; Phase oontrast

To assess a state and dynamics of the intracranial system noninvasively, intracranial compliance was measured with magnetic resonance imaging (MRI).The intracranial compliance (ICC) index was obtained from the ratio of the maximum intracranial volume loading change to the maximum pressure gradient change during the cardiac cycle, which were calculated from the net transcranial blood and cerebrospinal fluid (CSF) flow measured with phase-contrast (PC) cine MRI. ICC indices were determined in patients with normal pressure hydrocephalus (NPH), brain atrophy or asymptomatic ventricular dilation (VD), and in healthy volunteers. Concurrently, a time constant of the integral of the CSF wave response function, which represents the intracranial mechanical property was determined with PC cine MRI. The changes in ICE indices were also analyzed after intravenous injection of acetazolamide, i.e., hemodynamics independent. These values were then compared with the volume-pressure response (VPR) as a invasive compliance measurement during the shunt operations.The ICC index in the NPH group was significantly lower than in the control or VD group, but no difference was found between the control and VD groups. There was no significant change in the ICC index after acetazolamide injection. There were significant correlations between the ICC index and the time constant. A negative correlation was noted between the ICC index and the VPR.Compliance analysis with ICC index measured by PC cine MRI makes it possible to obtain noninvasively a more detailed intracranial state and dynamics in the NPH and to assist in diagnosis of the NPH.

为了无创性地评价颅内系统的状态和动力学，利用磁共振成像（MRI）测量颅内顺应性，颅内顺应性（ICC）指数由心动周期内最大颅内容积负荷变化与最大压力梯度变化的比值获得，根据相位对比（PC）电影MRI测量的净经颅血液和脑脊液（CSF）流量计算。在正常压力脑积水（NPH）、脑萎缩或无症状脑室扩张（VD）患者和健康志愿者中测定ICC指数。同时，用PC电影MRI测定了代表颅内力学特性的CSF波响应函数积分的时间常数。还分析了静脉注射乙酰唑胺后ICE指数的变化，即，血流动力学无关。结果NPH组的ICC指数明显低于对照组和VD组，而对照组和VD组之间无显著性差异。注射乙酰唑胺后ICC指数无显著变化。ICC指数与时间常数之间存在显著相关性。ICC指数与VPR呈负相关。通过PC电影MRI测量ICC指数进行顺应性分析，可以无创地获得NPH更详细的颅内状态和动力学，并有助于NPH的诊断。

项目成果

MRIによる正常圧水頭症の頭蓋内コンプライアンス解析

正常压脑积水颅内顺应性MRI分析

• 发表时间: 2005
• 期刊: 日本放射線技術学会雑誌 62-1
• 作者: Matsunaga S;Miyati T;Mase M;Kasai H;Nakajima H;Mori K;Kawamura F;Sugiyama M;Hara M;Shibamoto Y;Suzuki M;松永紗代子
• 通讯作者: 松永紗代子

Non-invasive measurement of intracranial compliance using cine MRI in normal pressure hydrocephalus

使用电影 MRI 无创测量正常压力脑积水的颅内顺应性

• 发表时间: 2005
• 期刊: Acta Neurochir 95
• 作者: Matsunaga S;Miyati T;Mase M;Kasai H;Nakajima H;Mori K;Kawamura F;Sugiyama M;Hara M;Shibamoto Y;Suzuki M;松永紗代子;Mitsuhito Mase
• 通讯作者: Mitsuhito Mase

MRI-intracranial compliance analysis in patients with NPH

NPH 患者的 MRI 颅内依从性分析

• 发表时间: 2006
• 期刊: Nippon Hoshasen Gijutsu Gakkai Zasshi 62-1
• 作者: Matsunaga S;Miyati T;Mase M;Kasai H;Nakajima H;Mori K;Kawamura F;Sugiyama M;Hara M;Shibamoto Y;Suzuki M
• 通讯作者: Suzuki M

正常圧水頭症における頭蓋内コンプライアンスのMRIによる定量評価

MRI定量评估正常压脑积水颅内顺应性

• 发表时间: 2004
• 期刊: 第5回日本正常圧水頭症研究会抄録集
• 作者: Matsunaga S;Miyati T;Mase M;Kasai H;Nakajima H;Mori K;Kawamura F;Sugiyama M;Hara M;Shibamoto Y;Suzuki M;松永紗代子;Mitsuhito Mase;間瀬光人;Mitsuhito Mase;間瀬光人;Tosiaki Miyati;間瀬光人
• 通讯作者: 間瀬光人

MRIによる頭蓋内コンプライアンスの非侵襲的定量評価-正常圧水頭症における検討-

MRI无创定量评估颅内顺应性 - 正常压力脑积水的研究 -

• 发表时间: 2005
• 期刊: Progress in Research on Brain Edema and ICP [2005]
• 作者: Matsunaga S;Miyati T;Mase M;Kasai H;Nakajima H;Mori K;Kawamura F;Sugiyama M;Hara M;Shibamoto Y;Suzuki M;松永紗代子;Mitsuhito Mase;間瀬光人;Mitsuhito Mase;間瀬光人
• 通讯作者: 間瀬光人