Experimental and clinical study of the treatment by acupuncture and moxibustion on the postoperative complaints after digestive surgery

针灸治疗消化道手术术后不适的实验与临床研究

• 批准号: 13671265
• 负责人: SAKITA Masakazu
• 金额: $ 2.56万
• 依托单位: Meiji University of Oriental Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671265/
• 关键词: acupuncture stimulation; gastro-intestinal motility; CCK; optokinetic motion sickness; electrogastrogram; 結腸運動; LSB; 鍼通電刺激; motion sickness

(1) To study the effect of electrical acupuncture (EA) on intestinal motility, we employed the strain gauge force transducer method to record the gastrointestinal motility of rats continuously and investigated the effects of drugs acting on the autonomic nervous function and EA on jejunal motility. Electrical stimulation to the abdomen caused the same reaction as neostigmin administration and irregular contractions continued for 5 hours after abdominal stimulation, and the frequency of IMC (Interdigestive myoelectric complex) increased during 1 to 3 hours after EA to the hind limbs.(2) To elucidate the mechanism of the effects of the EA colonic motility in rats and the role of cholecystokinin (CCK) in regulating them, the participation of the central CCK receptors and the changes of CCK-immunoreactivities in cerebrospinal fluid (CSF) were investigated. The results indicated that high frequency EA induces a significant release of CCK in CSF, which accelerate the colonic motility through the activation of central CCK-A receptors.(3) To investigate the effect of acupuncture stimulation at PC6 (Neiguan) on optokinetic motion sickness, motion sickness scores were evaluated and changes in electrogastrograms (EGG) were analyzed in each subject. Subjects were exposed to a rotating optokinetic drum to induce vection. EGG was recorded before, during, and after the rotation exposure. The severity of nausea which is one of main symptom of motion sickness was suppressed and the percentage of normal band of EGG activity was increased in the retaining needle group than in no treatment group. From these results, it was considered that the retaining needle stimulation of the PC6 acupoints was effective for optokinetic motion sickness possibly by suppressing abnormal gastric myoelectric activities.

(1)为研究电针对肠运动的影响，采用应变力传感器方法连续记录大鼠胃肠运动，观察药物对自主神经功能的影响及电针对空肠运动的影响。电刺激大鼠腹部可引起与注射新斯的明相同的反应，刺激后5h可持续不规则收缩，后肢电针后1~3h消化间期肌电复合体(IMC)频率增加。(2)为阐明电针对大鼠结肠运动的影响机制及CCK在其中的调节作用，观察了中枢CCK受体的参与及脑脊液中CCK免疫活性的变化。结果表明，高频电针可通过激活中枢CCK-A受体，诱导脑脊液中CCK的显著释放，从而促进结肠运动。(3)为探讨针刺内关穴对视动性运动病的影响，对各受试者进行了晕动病评分和胃电变化分析。受试者被暴露在旋转的视动鼓中以诱导视觉。在旋转暴露前、期间和之后记录EGG。留针组与非针刺组比较，主要症状之一恶心的严重程度得到抑制，胃电活动正常条带的百分率增加。由此可见，留针刺激PC6穴治疗视动性运动病可能是通过抑制胃异常肌电活动而起作用的。

项目成果

塩見 真由美: "胃電図を指標としたoptokinetic motion sicknessに対する鍼刺激の影響について"全日本鍼灸学会雑誌. 53(1). 71-80 (2003)

Mayumi Shiomi：“以胃电图为指标的针灸刺激对视动运动病的影响”全日本针灸学会杂志 53(1) (2003)。

Masahiro IWA: "Effect of Somatosensory Stimulation on Intestinal Motility in Conscious Rat Using Strain Gauge Force Transducer Method"Am. J. Chinese Med.. (in press).

Masahiro IWA：“使用应变计力传感器方法体感刺激对清醒大鼠肠道蠕动的影响”Am。

Masahiro IWA, Masakazu SAKITA: "Effect of somatosensory stimulation on intestinal motility in conscious rat using strain gauge force transducer method"Am. J. Chinese Med.. (in press).

Masahiro IWA、Masakazu SAKITA：“使用应变仪力传感器方法体感刺激对清醒大鼠肠道蠕动的影响”Am。

Mayumi SHIOMI, Kenji IMAI, Masakazu SAKITA: "Effect of acupuncture stimulation on optokinetic motion sickness monitored by electrogastrograms"Journal of the Japan Society of Acupuncture and Moxibustion. Vol. 53(1). 71-80 (2003)

Mayumi Shiomii、Kenji Imai、Masakazu SAKITA：“针刺刺激对胃电图监测的视动性晕动病的影响”日本针灸学会杂志。