Correlation between Histological Degree of Chondrosarcoma and Detection of MMps, ADAMTSs and TIPs

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Background: Malignant degree of human chondrosarcoma can be difficult to determine using only histological findings. We therefore assessed expressions of matrix metalloproteinases (MMPs), a disintegrin and metalloproteinase (ADAM) with thrombospondin motifs (ADAMTSs) and tissue inhibitor of metal I oprotei nases (TIMPs) in chondrosarcoma and ascertained relationships to histological degree of malignancy and prognosis.Materials and Methods: In 28 chondrosarcoma patients, inimunostaining was performed using antibodies for each of the proteins of MMP-2, 3, 7, 9, 13, ADAMTS-4, 5 and TIMP-1, 2, 3.Results: Chondrosarcoma were classified into 7, 15 and 6 cases in histologically malignant grade I, 11 and 111, respectively. All target proteins were expressed in. chondrosarcoma. Positive correlations (p<0.05) existed between immunostaining scores and histological grades for all proteins except MMP 9, with strong correlations (p<0.01) for MMPs 2, 3 and 13, both ADAMTSs and all 3 TIMPs. No correlation existed between prognosis and immunostaining scores.Conclusions: These proteins could thus indicate degree of malignancy in human chondrosarcoma.