MRI evaluation of cruciate ligaments-bone junction in rheumatoid arthritis.

在一些类风湿性关节炎（RA）患者中，滑膜炎症得到治疗控制，软骨破坏悄无声息地进行，最终导致关节成形术。RA关节破坏的起始和原发变化尚未明确。为了探讨类风湿关节炎关节破坏的发病机制，我们检测了胶原诱导性关节炎（CIA）患者血清中抗II型胶原抗体的水平和伴随软骨退变的显微镜改变。MRI检查关节软骨早期退变，以评价RA患者交叉韧带-骨连接的情况。在CIA中，外周膜及其周围形成软骨和骨髓之间的连接，对应于人类的软骨下区域。

In some of the rheumatoid arthritis (RA) patients, with therapeutically controlled synovial inflammation, cartilage destruction silently progresses, eventually leading to arthroplasty. Initiation and primary changes of joint destruction in RA have not yet been clarified. Inorder to approach the pathogenesis of joint destructionin RA, we examined serum levels of atiti-type II collagen antibodies and microscopic changes accompanying cartilage degeneration in collagen-induced arthritis(CIA). The early phase of cartilage degeneration was examined in order to evaluate of cruciate ligaments-bone junction in RA by MRI. In CIA, the periphysis and its surroundings form the junction between cartilage and bone marrow, corresponding to the subchondral area in humans.