The long-term use of magnesium has an effect on the skeletal muscle cells and the neuromuscular junctions.

长期使用镁对骨骼肌细胞和神经肌肉接头有影响。

• 批准号: 13671572
• 负责人: SATO Kosei
• 金额: $ 2.24万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671572/
• 关键词: magnesium; neuromuscuiar blocking drug; succinylcholine; acetylcholine receptor

We examined the serial electrolytes levels before and after rapid sequence induction of general anesthesia for cesarean section prospectively. 52 parturients scheduled for cesarean section under general anesthesia were enrolled into the study. After arterial cannulation and the measurements of blood electrolytes, patients were pretreated with vecuronium (0.5mg). Anesthesia was induced using sodium thiamylal (200mg) and succinylcholine (lOOmg) intravenously, and the trachea was rapidly intubated. Blood samples were obtained 2.5min. 5min. and lOmin. after administration of succinylcholine, then whole blood ionized electrolytes were analyzed.Patients were devided into 4 groups by the use of tocolytic agent and the treatment period before surgery. Group 1 patients were treated with ritodrine and magnesium for more than 1 week (RITODRINE+Mg>1W, n=5), Group2 patients were treated with ritodrine and magnesium for less than 1 week (RITODRINE+Mg<1W, n=5), Group3 patients were treated with only ritodrine (RITODRINE, n=28), Group4 patients were not treated with tocolytic agent (CONTROL, n=14).The serum potassium concentrations acquired before and 2.5min. after administration of succinylcholine were 4.0±0.6, 6.3±0.9 in Group 1, 3.5±0.2, 4.3±0.6 in Group2, 3.7±0.4, 4.1±0.9 in Group3, 3.8±0.2, 3.8±0.3 in Group4, respectively. Anesthetic induction with ketamine and vecuronium made no hyperkalemic reactions. A positive direct linear correlation between the duration of action of vecuronium and magnesium ion concentration was noted.We have attempted to establish the chronic haypermagnesmia rat model with the use of a micro-osmotic pump for histological studies. It has been very difficult to maintain the intended concentration of magnesium ion by using the pump. We should make a major breakthrough to establish the hypermagnesemia rat model.

我们前瞻性地检测了剖宫产术快速序贯全麻诱导前后的系列电解质水平。52名计划在全身麻醉下进行剖宫产的产妇入组研究。在动脉插管和血电解质测定后，患者用维库溴铵（0.5mg）预处理。使用硫代戊醛钠（200mg）和琥珀酰胆碱（100mg）静脉内诱导麻醉，并迅速插管。2.5min采血。5分钟。和10分钟。按术前是否使用安胎药及治疗时间分为4组。第1组患者口服利托君和镁剂治疗1周以上（利托君+镁> 1周，n=5），第2组为利托君+镁治疗少于1周（利托君+镁<1W，n=5），第3组仅用利托君第四组（n= 14）为对照组（n =14），分别于用药前及用药后2.5min测定血清钾浓度。琥珀胆碱组分别为4.0± 0.6，6.3 ±0.9，组2分别为3.5± 0.2，4.3 ±0.6，组3分别为3.7± 0.4，4.1 ±0.9，组4分别为3.8± 0.2，3.8 ±0.3。氯胺酮和维库溴铵麻醉诱导无高钾血症反应。维库溴铵的作用时间与镁离子浓度呈直线正相关。我们尝试用微量渗透泵建立慢性高镁血症大鼠模型，进行组织学研究。使用该泵很难保持预期的镁离子浓度。高镁血症大鼠模型的建立应取得重大突破。