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A clinical anatomical study of the arrangement of the intrapelvic fasciae and the distribution of the nerves with special reference to the relationships to the development of the urorectal space and the pelvic plexus

盆腔内筋膜排列和神经分布的临床解剖学研究，特别是与尿直肠间隙和盆腔神经丛发育的关系

基本信息

批准号：
13671639
负责人：
SAKAMOTO Hirokazu
金额：
$ 2.62万
依托单位：
Tsukuba College of Technology (2003)Tokyo Medical and Dental University (2001-2002)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

In a gross anatomical study, we investigated the spatial arrangement of the intrapelvic fasciae and the distribution of the branches of the pelvic plexus. The branches from the pelvic plexus to the urethral sphincter region generally originated from S4 as a lowest branch of the pelvic splanchnic nerve, and ran along the rectal attachment of the levator ani. Various connections were sometimes observed between the pudendal nerve and the branches medial to the levator ani. It is suggested that the somatic nerve fibers from the nerve to the levator ani or from the pudendal nerve might also join the nerve branches to the region from the pelvic plexus. In addition, we also investigated the branching patterns of the internal iliac artery.In a embryological study, to understand normal cloacal developmental processes, serial sagittal sections of mouse embryos were made every 6 h from embryonic day 11.5 (E11.5) to E13.5. During cloacal development to form the urogenital sinus and anorectal canal, fusion of the urorectal septum with the cloacal membrane was not observed, and the ventral and dorsal parts of the cloaca were continuously connected by the canal until disappearance of the cloacal membrane to open the vestibule formed by the urogenital sinus and anorectal canal to the outside at E13.5. In addtion, we investigated the spatiotemporal distribution of the apoptotic cells/bodies in the cloacal region. The present findings suggest that in the early stages (until E12.0), distribution of apoptosis in mesenchyme around the dorsal part of the cloaca might be strongly related to the transformation and ventral shifting of this part. Conversely, the apoptosis pattern in urorectal septum mesenchyme in later stages (from E12.0) might be involved in transformation of the urorectal septum and disintegration of the cloacal membrane.

在大体解剖学研究中，我们研究了盆内筋膜的空间排列和盆丛分支的分布。盆丛至尿道括约肌区的分支一般起源于盆内脏神经的最低分支S4，沿着肛提肌的直肠附着点。阴部神经与提肛肌内侧支之间有时可见不同的联系。提示：肛提肌神经或阴部神经的躯体神经纤维也可与盆丛至盆丛区的神经分支汇合。此外，我们还研究了髂内动脉的分支模式。在胚胎学研究中，为了了解正常泄殖腔发育过程，从胚胎第11.5天（E11.5）到E13.5，每6小时制作一次小鼠胚胎的连续矢状切片。在泄殖腔发育形成尿生殖窦和肛门直肠管的过程中，未观察到尿直肠隔与泄殖腔膜的融合，泄殖腔的腹侧和背侧部分通过该管连续连接，直至泄殖腔膜消失，将尿生殖窦和肛门直肠管形成的前庭打开。E13.5。此外，我们还研究了泄殖腔区凋亡细胞/体的时空分布。目前的研究结果表明，在早期阶段（直到E12.0），细胞凋亡分布在泄殖腔背侧部分周围的间充质可能强烈相关的转化和腹侧移位的这一部分。相反，在后期阶段（从E12.0）的尿直肠隔间充质细胞凋亡模式可能参与了尿直肠隔的转化和泄殖腔膜的解体。