Tumor growth inhibition and cancer prevention by serene enriched garlic in murine renal adenocarcinoma

富含宁静的大蒜对小鼠肾腺癌的肿瘤生长抑制和癌症预防作用

• 批准号: 13671672
• 负责人: FUJIOKA Tomoaki
• 金额: $ 2.24万
• 依托单位: IWATE MEDICAL UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671672/
• 关键词: garlic; serene; renal cell carcinoma; apoptosis; anti-tumor effect; 腎細細胞; アポートシス; 抗腫瘍効果; 大蒜; 抗腫瘍作用; 腎癌; 発癌予防

Renca was inoculated in BALB/c mice subcutaneously or renalsubcapsularly. Various concentrations of garlic powder in saline were administered orally every two days until the day 21 and tumor volumes and weights examined, apoptosis induction in the treated tumor was also investigated by TUNEL method and RT-PCR as to Bax and bcl-2 mRNA expression. Furthermore, the concentrations of serene in tissues and sera in Renca bearing mice were measured by ICP-MS. Renca growth was inhibited and apoptosis was also induced in the tumors by treatment in a dose-dependent manner. Lower concentration of serene in tumor tisses and sera in tumor bearing mice could be correct by the garlic treatment. These finding may be important not only the treatment of renal cancer but also in its prevention

RENCA在BALB/C小鼠中接种或肾脏刺激性。每两天口服每两天口服各种大蒜粉末，直到第21天，并检查了肿瘤的体积和体重，也通过Tunel方法和RT-PCR研究了处理过的肿瘤的凋亡诱导作为BAX和BCL-2 mRNA表达。此外，通过ICP-MS测量了组织中的宁静浓度和renca轴承小鼠的血清。 Renca生长受到抑制，并通过剂量依赖性方式在肿瘤中诱导凋亡。大蒜处理中，肿瘤组织中较低浓度的宁静和血清中的血清可能是正确的。这些发现不仅对肾癌的治疗也可能很重要，而且在预防方面也很重要

项目成果

福 文彦, 岩動 一将, 他: "マウス腎癌におけるニンニクの抗腫瘍効果"Biotherapy. 15(3). 359-362 (2001)

Fukuhiko Fuku、Kazumasa Iwado 等人：“大蒜对小鼠肾癌的抗肿瘤作用”生物疗法 15(3) 359-362 (2001)。

旗福文彦, 岩動一蒋, 小原 航, 加藤利基, 鈴木 泰, 藤岡知昭: "マウス腎癌におけるニンニクの抗腫瘍効果"Biotherapy. 15・3. 359-362 (2001)

Fumihiko Hatafuku、Kazumasa Iwado、Wataru Ohara、Toshiki Kato、Yasushi Suzuki、Tomoaki Fujioka：“大蒜对小鼠肾癌的抗肿瘤作用”15・3（2001）。

Hatafuku F, Isurugi M, Obara H, Kato T and Fujioka: "Tumor growth inhibition by garlic in murine renal Adenocarcinoma"Biotherapy. 15. 359-362 (2001)

Hatafuku F、Isurugi M、Obara H、Kato T 和 Fujioka：“大蒜对小鼠肾腺癌的肿瘤生长抑制作用”生物疗法。

旗福文彦, 岩動一将, 小原 航, 加藤利基, 鈴木 泰, 藤岡知昭: "マウス賢癌におけるニンニクの坑腫瘍効果"Biotherapy. 15. 359-362 (2001)

Fumihiko Hatafuku、Kazumasa Iwado、Wataru Ohara、Toshiki Kato、Yasushi Suzuki、Tomoaki Fujioka：“大蒜对小鼠癌症的抗肿瘤作用”生物疗法。

藤岡知昭: "ニンニク、セレニュウムと癌"IMMUNOBLADDER NEWS. 6. 18-21 (2002)

Tomoaki Fujioka：“大蒜、硒和癌症”免疫膀胱新闻。6. 18-21 (2002)