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A human monoclonal antibody (10-9D) that selectively recognizes human uterine endometrial carcinoma

A human monoclonal antibody (10-9D) that selectively recognizes human uterine endometrial carcinoma
选择性识别人子宫内膜癌的人单克隆抗体(10-9D)
批准号:
13671745
负责人:
TSUKAZAKI Katsumi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002

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中文摘要
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英文摘要
Our newly established human monoclonal antibody termed 10-9D (of IgM subclass) was found to recognized human uterine endometrial cancer carcinoma. Immunohistochemical staining revealed that the reactivity of 10-9D was position in 54.6% of uterine endometrial adenocarcinoma specimens furthermore , the monoclonal antibody does not react with either proliferative or secretory phase normal endometrium. Although slight positivity was observed in the epithelium of the collecting duct in the kidney and gallbladder, no staining was observed in a wide variety of other normal and malignant tissues. Carbohydrate analysis determined that the epitope structure for this antibody is a disulfated mucin-type Olinked carbohydrate structure. These characteristics implicate a possible future diagnostic as well as therapeutic role using the antibody
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会议论文
Yoshibumi Kaneta, Katsumi Tukazaki, Kaneyuki Kubushiro, et.al.: "Selective cytotoxicity of adriamycin immunoconjugate of monoclonal antibody MSN-1 to endometrial adenocarcinoma in vitro and in vivo"Oncology Reports. 7. 1099-1106 (2000)
Yoshibumi Kaneta、Katsumi Tukazaki、Kaneyuki Kubushiro 等人:“单克隆抗体 MSN-1 的阿霉素免疫缀合物对子宫内膜腺癌的体外和体内选择性细胞毒性”肿瘤学报告。
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Kaneyuki Kubushiro, Jun Ma, Katsumi Tsukazaki, et.al.: "Changes of β-1-4-Galactosyltransferase with the development of endometrial cancer"Gynecol.Obstet.Invest. 48(3). 211-14 (1999)
Kaneyuki Kubushiro、Jun Ma、Katsumi Tsukazaki 等人:“β-1-4-半乳糖基转移酶随子宫内膜癌发生的变化”Gynecol.Obstet.Invest 48(3) (1999)。
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久布白 兼行, 岩田 卓, 塚崎 克己: "Ia期FIGO分類とその取扱い"産婦人科治療. 82(2). 169-174 (2001)
Kaneyuki Kubushiro、Takashi Iwata、Katsumi Tsukazaki:“Ia 期FIGO 分类及其处理”妇产科治疗82(2)。
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久布白 兼行, 舛本 暢生, 岩田 卓, 塚崎 克己, 野澤 志朗: "子宮頸部円錐切除術における妊孕能温存"産科と婦人科. 68(8). 1024-1030 (2001)
Kaneyuki Kubushiro、Nobuo Masumoto、Takashi Iwata、Katsumi Tsukazaki、Shiro Nozawa:“宫颈锥切术中的生育能力”妇产科 68(8) (2001)。
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19
    The Analysis of glicosyltransferase involved in the cell biological function of gynecological cancers
    • 批准号:
      11671651
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.43万
    • 财政年份:
      1999
    • 负责人:
      TSUKAZAKI Katsumi
    • 依托单位:
    Alteration of endometrial cancer cell function caused by beta 1,4-galactosyl transferase gene induction.
    • 批准号:
      09671712
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.92万
    • 财政年份:
      1997
    • 负责人:
      TSUKAZAKI Katsumi
    • 依托单位:
    The mechanism and biological function of abnormal expression of fucosylated carbohydrate chains occurring after development of endometrial cancer
    • 批准号:
      07671821
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.54万
    • 财政年份:
      1995
    • 负责人:
      TSUKAZAKI Katsumi
    • 依托单位:
    study of the mechanism and role of fucosylated suger chains abnormal expression associated with uterine corpus cancer onset
    • 批准号:
      05671399
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.28万
    • 财政年份:
      1993
    • 负责人:
      TSUKAZAKI Katsumi
    • 依托单位: