ANALYSIS FOR ANDROGENIC EFFECT IN BONE HETABOLIIM

骨代谢受激素、细胞因子、矿物质等多种因素的影响。其中，激素在骨代谢中起着重要作用。雌激素是一种与骨代谢有关的重要激素，对其作用的研究已经有很多报道。另一方面，雄激素似乎也是骨代谢的一个重要因素。然而，研究雄激素在骨代谢中的作用是不够的。在本研究中，我们分析了雄激素受体阳性的人骨肉瘤细胞系的雄激素效应，该细胞系具有成骨能力。在该细胞系中，双氢睾酮（DHT）不诱导骨形成，而雌二醇和骨形态发生蛋白2（BMP 2）诱导骨形成。二氢睾酮抑制雌二醇和bhp2在骨形成中的作用。DHT还能抑制破骨细胞骨蛋白的表达，从而抑制破骨细胞的发育。综上所述，雄激素通过干扰雌二醇和BMP 2的作用来抑制骨形成，通过抑制骨蛋白素的表达来诱导骨吸收。雄激素在骨代谢中起重要作用。

Bone metabolism are affected by various factors such as hormone, cytokines mineral etc. Among them, hormones play an important role in bone metabolism. Estrogen is a very important hormone related to bone metabolism and a lot of studies for the role of estrogen have been reported. On the other hand, androgen seems to be also an important factor in bone metabolism. However, it is not enough to investigate the androgenic effect in bone metabolism. In this study, we analyzed the androgenic effect in human androgen receptor positive osteosarcoma cell line, which has ability to bone formation. In this cell line, dihydrotestosterone (DHT) did not induce the bone formation, whereas estradiol and bone morphogenic protein 2(BMP 2) showed the induction or bone formation. DHT suppressed the effect of estradiol and BHP 2 in bone formation. Moreover, DHT also suppressed the expression of osteoprotegrin which suppressed the development of osteoclast. In summary, androgen shows the suppressive effect in bone formation by interfering the effect of estradiol and BMP 2 and inducible effect in bone absorption by the suppression of the expression of osteoprotegrin. Androgen play an important role in bone metabolism.