Analysis of retinal function using P3-and derived P2-models and ON/OFF ERG responses

这项名为《使用P3和派生的P2模型分析视网膜功能和开/关ERG反应》的研究试图使用视杆和锥体a波(P3)模型、派生的P2模型和长时间闪光刺激下的开/关ERG反应来分析正常对照组和各种眼科疾病患者的视网膜功能。首先，我们记录了30名正常志愿者对200毫秒闪光刺激的常规(暗视和明视)ERG和开/关反应，并测量了各波成分(a波、b波、d波、OP波等)的振幅和峰潜伏期的正常值。然后，我们计算了正常对照组P3和P2模型的参数(Rm、S、Td等)。对各种眼科疾病(如视网膜色素变性、视锥细胞营养不良、先天性视网膜劈裂、Oguchi病、维生素A缺乏症、视网膜中央静脉阻塞)的检测结果与正常对照组进行比较。对患者的其他眼科检查结果进行了分析，包括视力、视野、眼印度教徒、暗适应曲线、基因分析等，有助于患者从多项检查中客观地了解准确的视网膜功能。本研究提供的评估视网膜功能的新的ERG方法将在不久的将来应用于视网膜变性的基因治疗和视网膜移植。

The study, entitled "Analysis of retinal function using P3-and derived P2-models and ON/OFF ERG responses", tried to analyze retinal function in normal controls and patients with various ophthalmological diseases using rod and cone a-wave(P3) models, derived P2 model, and ON/OFF ERG responses to long flash stimulation.At first we recorded conventional(scotopic and photopic) ERGs and ON/OFF responses to 200 msec flash stimulation in 30 normal volunteers, and measured the normal values of amplitudes and peak latencies from the wave components (a-,b-,d-, OP-waves, and so on). After that, we calculated the parameters(Rm,S,td,etc) of the P3-and derived P2-models in normal controls. The values from various patients with ophthalmological disease(ex.retinitis pigmentosa, cone dystrophy, congenital retinoschisis, Oguchi disease, vitamin A deficiency, central retinal vein occlusion) were compared with those from normal controls. Other results of ophthalmological examinations, including visual acuity, visual field, ocular Hindus, dark adaptation curves, gene analysis, were also analyzed in the patients.It would be beneficial for patients to see the precise retinal function objectively from several examinations. New ERG methods to estimate retinal function shown in this study would be used in gene therapy and retinal transplantation in retinal degeneration in the near future.