Examination of application of photocatalyst titanium oxide in dentistry and mouth domain

光触媒氧化钛在牙科口腔领域的应用探讨

• 批准号: 13671922
• 负责人: WATANABE Yoshihisa
• 金额: $ 1.86万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671922/
• 关键词: photocatalyst; titanium oxide (Tio2); atineoplastic (antitumor); guard bacterium effect; oral cancer; tumor; the artificial material for dentistries; 口腔癌腫瘍; 口腔癌治療

Research which turns a TiO_2 photocatalyst reaction to the utilization of a life object (medical apparatus and medicine material) is advanced. The application of oral cancer medical treatment by the sterilization effect, (guard dirty) and TiO_2 particle by coating of TiO_2 to the artificial material for dentistries. Additionally optical irradiation was tried for the purpose of application to the dentistry medical treatment of a TiO_2 photocatalyst reaction, and the medical treatment of an oral surgery domain. This research is considered the development of high medical treatment methods of safety to disease of dentistry mouth domain.Examination of the application to oral cancer medical treatment of TiO_2 photocatalyst particle TiO_2 particle. The antineoplastic drugs (adraremaishin) were used together in the culture solution of oral cancer origin established cultivation cell (SCC, ACC). UV irradiation after addition was performed, and the level of in vitro examined againtist cancer cell … More effect. In order to introduce efficiently the examination of TiO_2 photocatalyst particle about the anti-neoplasm effect in a nude-mouse (Balb/c). A solid type cancer (SCC and ACC) in a cancer organization, the cartridge of the heredity gun in which TiO_2 was coated to a golden particle was manufactured. Furthermore, after driving the coated particle with gold (TiO_2) and the antineoplastic drug in a neoplasm organization using a gene gun, optical irradiation was performed and examination of the anti-neoplasm effect was performed.With the pathology organization study-view, the antineoplastic drug and the photocatalyst TiO_2 adhesion golden particle were observed in part with all epithelium layers. Focusing on the cornification layer of rats mouth membrane epithelium by the bottom connective tissue of an epithelium as a minute particle of dark brown. Moreover, change was not accepted in the pathology organizational study. The group which did not carry out UV irradiation after inserting an antineoplastic drug and a photocatalyst TiO_2 adhesion golden. Particle observed the bubble formation view ad the epithelium deficit (ulcer view). Uunder the epithelium one-two days after pathology organizational study. It was suggested from this result that the model-effect exertion which adjusts the organizations susceptibility of medicines, such as an antineoplastic drug, by UV irradiation On-Off can expect TiO_2Now, examination about the local effect of medicines, such as an antineoplastic drug in a pathological change part (neoplasm organization), was performed. It started about the experiment of the judgment of the medical treatment. It effect by carrying out On-Off control a medicine from optical irradiation's.Second, TiO_2 was added to the resin material used at the time of dentistry dental caries medical treatment, and guard bacterium effect over dental caries was examined. Furthermore, the experimental examination towards guard bacterium effect over mouth infection including a periodontium disease and its utilization is continued. Less

将TiO_2光催化反应转化为生命体（医疗器械和药物材料）利用的研究正在推进。通过对口腔癌医疗中的杀菌效果、防垢效果和TiO_2颗粒的包覆，将TiO_2应用于牙科用人工材料。此外，还尝试将光照射应用于TiO_2光催化剂反应的牙科医疗和口腔外科领域的医疗。本研究旨在开发对口腔科疾病安全性高的医疗手段，探讨TiO_2光催化剂微粒TiO_2微粒在口腔癌医疗中的应用。在口腔癌来源的已建立的培养细胞（SCC、ACC）的培养液中，联合使用抗肿瘤药物（阿霉素）。加入后进行紫外线照射，体外检测抗肿瘤细胞水平 ...更多信息 效果为了有效地介绍TiO_2光催化剂微粒在裸鼠体内抗肿瘤作用的检测。针对某肿瘤组织中的实体癌（SCC和ACC），研制了以TiO_2为涂层的金粒子遗传枪药筒。此外，在用基因枪将涂覆有金（TiO_2）的颗粒和光催化剂TiO_2在肿瘤组织中驱动后，进行光照射并进行抗肿瘤效果的检查，用病理组织学研究视图，在所有上皮层中部分地观察到光催化剂TiO_2粘附金颗粒。在大鼠口腔粘膜上皮的角化层中，由上皮的底部结缔组织聚焦成一个深褐色的微小颗粒。此外，在病理学组织研究中不接受变化。未进行紫外线照射的组在插入光催化剂TiO_2和光催化剂TiO_2后呈金黄色。颗粒观察到气泡形成视图和上皮缺损（溃疡视图）。术后1 ~ 2天取上皮下组织进行病理组织学研究。从该结果可以看出，通过UV照射开-关来调节药物（如抗癌药物）的组织敏感性的模型效应发挥可以预期TiO_2。现在，进行关于药物（如抗癌药物）在病变部分（肿瘤组织）中的局部效应的检查。它始于医疗判断的实验。其次，将TiO_2添加到牙科龋病治疗时使用的树脂材料中，考察其对龋病的防护作用。此外，对口腔感染包括牙周疾病的防护细菌作用及其应用的实验研究仍在继续。少

项目成果

田中久美子, 窪田吉信, 飯野光代, 三好代志子, 渡辺是久, 藤嶋昭 等: "Tio2コーティング金粒子を用いた疾患治療への基礎的検討 第2報"会報 光触媒 光触媒反応の最近と展開. 12. 208-209 (2003)

Kumiko Tanaka、Yoshinobu Kubota、Mitsuyo Iino、Yoshiko Miyoshi、Korehisa Watanabe、Akira Fujishima 等人：“使用 Tio2 包覆金颗粒进行疾病治疗的基础研究，第二份报告” Newsletter Photocatalyst 光催化反应的最新进展。 209（2003）

田中久子, 窪田吉信, 飯野光代, 三好代志子, 渡辺是久, 藤嶋昭 等: "Tio2コーティング金粒子を用いた疾患治療への基礎的検討"会報 光触媒 光触媒反応の最近と展開. 9. 112-113 (2002)

Hisako Tanaka、Yoshinobu Kubota、Mitsuyo Iino、Yoshiko Miyoshi、Korehisa Watanabe、Akira Fujishima 等人：“利用 Tio2 包覆金颗粒进行疾病治疗的基础研究” 光催化剂通报 光催化反应的最新进展和进展 9. 112-113（ 2002）

田中久美子, 窪田吉信, 飯野光代, 三好代志子, 渡辺是久, 藤嶋昭 等: "Tio2コーティング金粒子を用いた疾患治療への基礎的検討"会報 光触媒 光触媒反応の最近と展開. 9. 112-113 (2002)

Kumiko Tanaka、Yoshinobu Kubota、Mitsuyo Iino、Yoshiko Miyoshi、Korehisa Watanabe、Akira Fujishima 等人：“使用 Tio2 涂层金颗粒进行疾病治疗的基础研究” 光催化剂通报 光催化反应的最新进展 9. 112-113 (2002)。

N Usui, Y Kubota, C Niwa, Y Sekiguchim Y Miyoshi, A Fujishima et al.: "Tio2 coating silicone surfaces and their application to self-sterilizing medical tubes and catheters"14^<th> International conference on Photochemical Conversion and Storage of Solar E

N Usui, Y Kubota, C Niwa, Y Sekiguchim Y Miyoshi, A Fujishima 等：“Tio2 涂层有机硅表面及其在自消毒医疗管和导管中的应用”14^<th>光化学转换和存储国际会议

田中久美子, 窪田吉信, 飯野光代, 三好代志子, 渡辺是久, 藤嶋昭 等: "Tio2コーティング金粒子を用いた疾患治療への基礎的検討 第2報"会報 光触媒 光触媒反応の最近と展開. 13. 208-209 (2003)

Kumiko Tanaka、Yoshinobu Kubota、Mitsuyo Iino、Yoshiko Miyoshi、Korehisa Watanabe、Akira Fujishima 等人：“使用 Tio2 包覆金颗粒进行疾病治疗的基础研究，第二份报告” Newsletter Photocatalyst 光催化反应的最新进展 13. 208-。 209（2003）