EFFECT OF ADDITION OF ANTIBIOTICS ON PHYSICAL PROPERTIES OF AN EXPERIMENTAL CEMENT PREPARED FROM TETRACALCIUM PHOSPHATE AND POLY(METHYL VINYL ETHER-MALEIC ACID)

我们之前报道过将磷酸四钙与聚甲基乙烯醚-马来酸PMVE-Ma（质量分数=20-30%）混合可以制备聚合磷酸钙水泥。本研究的目的是研究添加抗生素对实验水泥机械强度的影响以及抗生素从水泥中释放的情况。本研究使用甲硝唑、头孢克洛、环丙沙星三种抗生素。将每种抗生素含量为5 wt%的水泥粉与25 wt%的PMVE-Ma水溶液混合，粉液质量比为3.0/1.0。水泥样品浸泡在37℃的水中。测定100小时内抗生素、钙、磷酸盐的释放量。浸渍24小时后测定其抗压强度。释放行为因添加的抗生素种类而异。三种抗生素中，环丙沙星的洗脱量最低。抗生素的掺入增加了钙的洗脱，磷酸盐的洗脱不受抗生素掺入的影响。抗生素的掺入降低了抗压强度。抗压强度降低的程度因抗生素的种类而异。与市售的含有抗生素的磷酸钙水泥相比，头孢克洛的加入降低了水泥的抗压强度值。

We previously reported that a polymeric calcium phosphate cement can be prepared by mixing tetracalcium phosphate with poly(methyl vinyl ether-maleic acid), PMVE-Ma (mass fraction=20-30%). The aim of this study was to examine the effects of addition of antibiotics on the mechanical strength of the experimental cement and the release profile of the antibiotics from the cement. Three kinds of antibiotics, Metronidazole, Cefaclor, or Ciprofloxacin were used in this study. The cement powders containing 5 wt % of each antibiotics were mixed with 25 wt% of PMVE-Ma aqueous solution at a powder/liquid ratio of 3.0/1.0 by mass. The cement samples were immersed in water at 37℃. The released antibiotics, Ca and phosphate were determined for 100 hours. The compressive strength was also measured after 24-hour immersion.The release behavior varied depending on the types of antibiotics added. The amount of Ciprofloxacin eluted from the cement was lowest in those of three antibiotics. The incorporation of antibiotics increased the elution of Ca. The elution of phosphate was not affected by the incorporation of antibiotics. The incorporation of antibiotics decreased the compressive strength. The degree of the decrease in compressive strength varied depending on the type of antibiotics. The addition of Cefaclor mostly lowered the value of the compressive strength, which compared to those of the commercially available calcium phosphate cements containing antibiotics.