EFFECT OF ADDITION OF ANTIBIOTICS ON PHYSICAL PROPERTIES OF AN EXPERIMENTAL CEMENT PREPARED FROM TETRACALCIUM PHOSPHATE AND POLY(METHYL VINYL ETHER-MALEIC ACID)

添加抗生素对磷酸四钙和聚甲基乙烯基醚马来酸制备的实验水泥物理性能的影响

• 批准号: 13672003
• 负责人: MATSUYA Yoko
• 金额: $ 2.3万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672003/
• 关键词: tetracalcium phosphate; polymeric acid; dental cement; compressive strength; antibiotics; dissolution; ポリメチルビニルエーテルマレイン酸; メトロニダゾール; セファクロル; シプロフロキサシン

We previously reported that a polymeric calcium phosphate cement can be prepared by mixing tetracalcium phosphate with poly(methyl vinyl ether-maleic acid), PMVE-Ma (mass fraction=20-30%). The aim of this study was to examine the effects of addition of antibiotics on the mechanical strength of the experimental cement and the release profile of the antibiotics from the cement. Three kinds of antibiotics, Metronidazole, Cefaclor, or Ciprofloxacin were used in this study. The cement powders containing 5 wt % of each antibiotics were mixed with 25 wt% of PMVE-Ma aqueous solution at a powder/liquid ratio of 3.0/1.0 by mass. The cement samples were immersed in water at 37℃. The released antibiotics, Ca and phosphate were determined for 100 hours. The compressive strength was also measured after 24-hour immersion.The release behavior varied depending on the types of antibiotics added. The amount of Ciprofloxacin eluted from the cement was lowest in those of three antibiotics. The incorporation of antibiotics increased the elution of Ca. The elution of phosphate was not affected by the incorporation of antibiotics. The incorporation of antibiotics decreased the compressive strength. The degree of the decrease in compressive strength varied depending on the type of antibiotics. The addition of Cefaclor mostly lowered the value of the compressive strength, which compared to those of the commercially available calcium phosphate cements containing antibiotics.

我们以前报道过，可将磷酸四钙与聚（甲基乙烯基醚-马来酸）（PMVE-Ma）（质量分数=20-30%）混合制备聚合磷酸钙骨水泥。本研究的目的是检查添加抗生素对实验骨水泥的机械强度和抗生素从骨水泥中的释放曲线的影响。本研究使用了甲硝唑、头孢克洛和环丙沙星三种抗生素。将含有5重量%的每种抗生素的水泥粉末与25重量%的PMVE-Ma水溶液以3.0/1.0质量的粉/液比混合。将水泥样品浸入37℃的水中。测定100小时释放的抗生素、钙和磷酸盐。浸泡24小时后测定其抗压强度，不同抗生素的释放行为不同。三种抗生素中环丙沙星的洗脱量最低。抗生素的加入增加了Ca的洗脱。磷酸盐的洗脱不受抗生素掺入的影响。抗生素的掺入降低了抗压强度。抗压强度降低的程度取决于抗生素的类型。与市售的含抗生素的磷酸钙骨水泥相比，头孢克洛的加入主要降低了抗压强度值。

项目成果

Sales D, Sae-Lee D, Matsuya S, Dewi Ana I: "Short-term fluoride and cations release from polyacid-modified composites in a distilled water and an acidic lactate buffer"Biomaterials. (in press).

Sales D、Sae-Lee D、Matsuya S、Dewi Ana I：“蒸馏水和酸性乳酸缓冲液中的多元酸改性复合材料短期释放氟化物和阳离子”生物材料。

Akashi, A., Matsuya Y., Unemori M. and Akamine A..: "Effect of antimicrobial agents on physical properties of dental cements"Key Engineering Materials. 192-195. 905-908 (2001)

Akashi, A.、Matsuya Y.、Unemori M. 和 Akamine A..：“抗菌剂对牙科水泥物理性能的影响”关键工程材料。

Akashi A., Matsuya Y., Unemori M. and Akamine A.: "Release profile of antimicrobial agents from α-tricalcium phosphate cement"Biomaterials. 22・20. 2713-2717 (2001)

Akashi A.、Matsuya Y.、Unemori M. 和 Akamine A.：“α-磷酸三钙水泥的抗菌剂释放曲线”生物材料 22・20 2713-2717。

Unemori M., Matsuya Y., Akashi A., Goto Y. and Akamine A.: "Composite resin restoration and postoperative sensitiveity: clinical follow-up in an undergraduate program"Journal of Dentistry. 29. 7-13 (2001)

Unemori M.、Matsuya Y.、Akashi A.、Goto Y. 和 Akamine A.：“复合树脂修复和术后敏感性：本科课程的临床随访”牙科杂志。

Sales D., Sae-Lee D., Matsuya S. and Dewi Ana I.: "Short-term fluoride and cations release from polyacid-modified composites in a distilled water and an acidic lactate buffer"Biomaterials. (in press).

Sales D.、Sae-Lee D.、Matsuya S. 和 Dewi Ana I.：“蒸馏水和酸性乳酸缓冲液中的多酸改性复合材料短期释放氟化物和阳离子”生物材料。