Relationship between Psychoendocrine Responses and Amount of Secretion of Estrogen in TMD Patients

TMD患者心理内分泌反应与雌激素分泌量的关系

• 批准号: 13672056
• 负责人: ISHIKAWA Tadashi
• 金额: $ 2.11万
• 依托单位: The Nippon Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672056/
• 关键词: Temporomandibular Disorders; Sex Hormone; Emotional Stress; Amount of Estrogen Secretion; 筋痛; 精神内分泌反応; 圧痛スコア

Recently, much attention was paid on the relation between masticatory muscular pain and sex hormone, estrogen to be specific. However researches that compared the amount of secretion of estrogen in TMD patients were not found.In this experiment the indicators for emotional stress and sex hormone of urine and blood samples taken from TMD patients were investigated.The concentration of plasma adrenaline, plasma nor adrenaline, plasma L dopamine, and serum cortisol measured from blood sample taken between 8:30 and 9:00 a.m., and the excretion of urine adrenaline, urine nor adrenaline, urine dopamine, and urine 17-OHCS measured from 24 hour urine were used as the indicators for emotional stress. The concentration of blood estrone and blood estradiol, and the excretion of urine estrone and urine estradiol were used as the indicators for sex hormone. The values of all the indicators were compared with normal values. Then the relationship between the emotional stress and the sex hormone was investigated. The values of indicators for both the emotional stress and the sex hormone were larger than normal values. The values of indicators representing emotional stress were high when the values of indicators representing sex hormone were high, and there was a significantly positive relation between the many two indicators. From these results it was suggested that the indicator values for emotional stress and sex hormone of TMD patients tend to be high, and the emotional stress of TMD patients was strongly related to the sex hormone.

近年来，咀嚼肌疼痛与性激素，具体来说是雌激素的关系受到广泛关注。本实验对TMD患者的尿和血中的情绪应激和性激素指标进行了研究，分别测定了8：30 ~ 9：00的血浆肾上腺素、血浆去甲肾上腺素、血浆L-多巴胺和血清皮质醇的浓度，并将尿肾上腺素、尿去甲肾上腺素、尿多巴胺和从24小时尿中测量的尿17-OHCS的排泄量用作情绪应激的指标。以血雌酮、血雌二醇浓度、尿雌酮、尿雌二醇排泄量作为性激素指标。并与正常值进行比较。探讨情绪应激与性激素水平的关系。情绪应激和性激素指标值均高于正常值。当性激素指标值高时，代表情绪压力的指标值也高，且多项指标之间呈显著正相关。提示TMD患者的情绪应激指标值和性激素指标值均偏高，且TMD患者的情绪应激与性激素密切相关。

项目成果

小林義典 他: "女性側頭下顎障害患者における情動ストレスと性ホルモンとの関係"第16回日本顎関節学会総会・学術大会. (発表予定).

Yoshinori Kobayashi等人：“女性颞下颌疾病患者情绪压力与性激素的关系”第16届日本颞下颌关节学会年会暨学术会议（报告预定）。

小林義典 他: "側頭下顎障害患者における情動ストレス-血中エストロゲンとの関係-"第15回日本顎関節学会総会・学術大会、プログラム・抄録集. 109 (2002)

Yoshinori Kobayashi 等人：“颞下颌疾病患者的情绪压力 - 与血液雌激素的关系”，日本颞下颌关节学会第 15 届年会，议程和摘要 109（2002 年）。

小林義典 他: "女性側頭下顎障害患者における情動ストレスと尿中エストロゲンとの関係"第17回日本歯科心身医学会学術大会,プログラム・抄録集. 46 (2002)

Yoshinori Kobayashi等人：“颞下颌疾病女性患者情绪压力与尿雌激素的关系”第17届日本牙科和心身医学会年会，议程和摘要46（2002年）。

Yoshinori Kobayashi, Tadasbi Ishikawa, Hiroshi Shiga, Ichiro Arakawa, and Takehiro Okamura: "The Relationship between Emotional Stress and Urine Estrogen in female TMD Patients"The 17th Annual Meeting of the Japanese Society of Psychosomatic Dentistry, Pr

Yoshinori Kobayashi、Tadasbi Ishikawa、Hiroshi Shiga、Ichiro Arakawa、Takehiro Okamura：“女性 TMD 患者情绪压力与尿液雌激素的关系”日本心身牙科学会第 17 届年会，Pr

Tadashi Ishikawa et al.: "Psychoendocrine Responses and Amount of Secretion of Estrogen in TMD Patients"2^<nd> Biennial Meeting of Asian Academy of Prosthodontics, Program and Abstracts of Papers. 41 (2001)

Tadashi Ishikawa 等人：“TMD 患者的心理内分泌反应和雌激素分泌量”第 2 届亚洲修复学学会双年会、议程和论文摘要。