Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
性激素调节外侧缰核电路的奖赏和厌恶编码
基本信息
- 批准号:10313129
- 负责人:
- 金额:$ 7.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAndrogensAnhedoniaAnti-Anxiety AgentsAnxietyAttenuatedAutomobile DrivingAversive StimulusBar CodesBehaviorBehavior DisordersBehavioralBrainCell NucleusClustered Regularly Interspaced Short Palindromic RepeatsCodeCognitionComplexCuesDataData SetDesire for foodElectric StimulationElectrophysiology (science)ElementsEstradiolEstrogensEtiologyExposure toFemaleFiberFire - disastersFluorescent in Situ HybridizationFunctional disorderGene ExpressionGenesGonadal Steroid HormonesHabenulaHormone ReceptorHormonesKnock-outKnowledgeLateralLesionMachine LearningMental DepressionMental disordersMolecularMonitorMotivationNamesNegative ValenceNeuronsNuclear Hormone ReceptorsOutputPatternPositive ValenceProgesteroneQuinineResearch ProposalsRewardsRodentRoleSex DifferencesSignal TransductionSpecificitySteroidsStressSucroseSumSystemTaste PerceptionTechnologyTestingTestosteroneTrainingUncertaintyVentral Tegmental AreaViralWorkaddictionbasebiological adaptation to stresscalcium indicatorcell typedata resourcedepressive symptomsdorsal raphe nucleusexperimental studyhormonal signalshormone regulationinsightmalemental setmood regulationmotivated behaviorneural circuitneuropsychiatric disorderneuropsychiatryneuroregulationneurotechnologynew therapeutic targetnonhuman primaterelating to nervous systemresponsereward circuitryreward processingsteroid hormonesteroid hormone receptortherapeutic targettool
项目摘要
Project Summary
This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through
mapping of Lateral Habenula (LHb) circuits. The LHb is a central hub important for encoding aversive information
and coordinating motivated behaviors, actions critical for survival. Dysfunction in LHb-dependent circuits
contribute to a diverse set of disordered behaviors, such as aberrant processing of positive and negative valence,
anhedonia, depressive symptomology, and maladaptive stress response, to name a few. While it is known that
motivated behaviors are modulated by circulating sex hormones, no studies have investigated whether negative
circuit regulators, specifically projections from the LHb, contribute to this phenomenon. Furthermore, nuclear
hormone receptors in the brain have not been well characterized, therefore understanding their role within LHb
reward circuits and how they interact with circulating hormones will provide insight into mechanisms driving sex
hormone effects on reward-related behaviors. In this proposal, by taking advantage of the most recent
technologies to define, manipulate, and monitor neural activity, I plan to test the functional contribution of specific
hormone receptors on molecularly defined LHb projection neurons on reward and aversion-related behaviors.
项目摘要
这项提案旨在调查性激素对奖励和厌恶相关行为的影响,
侧缰(LHb)回路的映射。LHb是编码厌恶信息的重要中枢
和协调有动机的行为,对生存至关重要的行动。LHb依赖性电路的功能障碍
导致了一系列不同的无序行为,例如正负价的异常处理,
快感缺乏症、抑郁性精神病学和适应不良应激反应,仅举几例。虽然已知
动机行为是由循环性激素调节的,没有研究调查是否消极
电路调节器,特别是来自LHb的突起,促成了这种现象。此外,核
大脑中的激素受体尚未得到很好的表征,因此了解它们在LHb中的作用
奖励回路以及它们如何与循环激素相互作用,将为我们提供有关性驱动机制的见解。
激素对奖赏相关行为的影响。在这项建议中,通过利用最新的
技术来定义,操纵和监测神经活动,我计划测试特定的功能贡献
LHb投射神经元上的激素受体对奖赏和厌恶相关行为的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brandy A. Briones其他文献
Variability in sampling of cortex-wide neural dynamics explains individual differences in functional connectivity and behavioral phenotype
全皮层神经动力学采样的变异性解释了功能连接和行为表型的个体差异
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Camden J. MacDowell;Brandy A. Briones;Michael J. Lenzi;Morgan L. Gustison;T. J. Buschman - 通讯作者:
T. J. Buschman
Cholinergic interneurons mediate cocaine extinction through similar plasticity across medium spiny neuron subtypes
胆碱能中间神经元通过中型多棘神经元亚型的相似可塑性介导可卡因消退
- DOI:
10.1101/2021.08.29.458113 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Weston Fleming;Junuk Lee;Brandy A. Briones;S. Bolkan;Ilana B. Witten - 通讯作者:
Ilana B. Witten
Differences in the expression of cortex-wide neural dynamics are related to behavioral phenotype
全皮层神经动力学表达的差异与行为表型有关
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:9.2
- 作者:
Camden J. MacDowell;Brandy A. Briones;Michael J. Lenzi;Morgan L. Gustison;T. J. Buschman - 通讯作者:
T. J. Buschman
Brandy A. Briones的其他文献
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{{ truncateString('Brandy A. Briones', 18)}}的其他基金
Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
性激素调节外侧缰核电路的奖赏和厌恶编码
- 批准号:
10531544 - 财政年份:2022
- 资助金额:
$ 7.37万 - 项目类别:
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