Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
性激素调节外侧缰核电路的奖赏和厌恶编码
基本信息
- 批准号:10313129
- 负责人:
- 金额:$ 7.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAndrogensAnhedoniaAnti-Anxiety AgentsAnxietyAttenuatedAutomobile DrivingAversive StimulusBar CodesBehaviorBehavior DisordersBehavioralBrainCell NucleusClustered Regularly Interspaced Short Palindromic RepeatsCodeCognitionComplexCuesDataData SetDesire for foodElectric StimulationElectrophysiology (science)ElementsEstradiolEstrogensEtiologyExposure toFemaleFiberFire - disastersFluorescent in Situ HybridizationFunctional disorderGene ExpressionGenesGonadal Steroid HormonesHabenulaHormone ReceptorHormonesKnock-outKnowledgeLateralLesionMachine LearningMental DepressionMental disordersMolecularMonitorMotivationNamesNegative ValenceNeuronsNuclear Hormone ReceptorsOutputPatternPositive ValenceProgesteroneQuinineResearch ProposalsRewardsRodentRoleSex DifferencesSignal TransductionSpecificitySteroidsStressSucroseSumSystemTaste PerceptionTechnologyTestingTestosteroneTrainingUncertaintyVentral Tegmental AreaViralWorkaddictionbasebiological adaptation to stresscalcium indicatorcell typedata resourcedepressive symptomsdorsal raphe nucleusexperimental studyhormonal signalshormone regulationinsightmalemental setmood regulationmotivated behaviorneural circuitneuropsychiatric disorderneuropsychiatryneuroregulationneurotechnologynew therapeutic targetnonhuman primaterelating to nervous systemresponsereward circuitryreward processingsteroid hormonesteroid hormone receptortherapeutic targettool
项目摘要
Project Summary
This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through
mapping of Lateral Habenula (LHb) circuits. The LHb is a central hub important for encoding aversive information
and coordinating motivated behaviors, actions critical for survival. Dysfunction in LHb-dependent circuits
contribute to a diverse set of disordered behaviors, such as aberrant processing of positive and negative valence,
anhedonia, depressive symptomology, and maladaptive stress response, to name a few. While it is known that
motivated behaviors are modulated by circulating sex hormones, no studies have investigated whether negative
circuit regulators, specifically projections from the LHb, contribute to this phenomenon. Furthermore, nuclear
hormone receptors in the brain have not been well characterized, therefore understanding their role within LHb
reward circuits and how they interact with circulating hormones will provide insight into mechanisms driving sex
hormone effects on reward-related behaviors. In this proposal, by taking advantage of the most recent
technologies to define, manipulate, and monitor neural activity, I plan to test the functional contribution of specific
hormone receptors on molecularly defined LHb projection neurons on reward and aversion-related behaviors.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Brandy A. Briones其他文献
Variability in sampling of cortex-wide neural dynamics explains individual differences in functional connectivity and behavioral phenotype
全皮层神经动力学采样的变异性解释了功能连接和行为表型的个体差异
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
Camden J. MacDowell;Brandy A. Briones;Michael J. Lenzi;Morgan L. Gustison;T. J. Buschman - 通讯作者:
T. J. Buschman
Cholinergic interneurons mediate cocaine extinction through similar plasticity across medium spiny neuron subtypes
胆碱能中间神经元通过中型多棘神经元亚型的相似可塑性介导可卡因消退
- DOI:
10.1101/2021.08.29.458113 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Weston Fleming;Junuk Lee;Brandy A. Briones;S. Bolkan;Ilana B. Witten - 通讯作者:
Ilana B. Witten
Differences in the expression of cortex-wide neural dynamics are related to behavioral phenotype
全皮层神经动力学表达的差异与行为表型有关
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:9.2
- 作者:
Camden J. MacDowell;Brandy A. Briones;Michael J. Lenzi;Morgan L. Gustison;T. J. Buschman - 通讯作者:
T. J. Buschman
Brandy A. Briones的其他文献
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{{ truncateString('Brandy A. Briones', 18)}}的其他基金
Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding
性激素调节外侧缰核电路的奖赏和厌恶编码
- 批准号:
10531544 - 财政年份:2022
- 资助金额:
$ 7.37万 - 项目类别:
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