Sex hormone regulation of Lateral Habenula circuitry for reward and aversion encoding

性激素调节外侧缰核电路的奖赏和厌恶编码

• 批准号: 10313129
• 负责人: Brandy A. Briones
• 金额: $ 7.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10313129
• 关键词: Address; Androgens; Anhedonia; Anti-Anxiety Agents; Anxiety; Attenuated; Automobile Driving; Aversive Stimulus; Bar Codes; Behavior; Behavior Disorders; Behavioral; Brain; Cell Nucleus; Clustered Regularly Interspaced Short Palindromic Repeats; Code; Cognition; Complex; Cues; Data; Data Set; Desire for food; Electric Stimulation; Electrophysiology (science); Elements; Estradiol; Estrogens; Etiology; Exposure to; Female; Fiber; Fire - disasters; Fluorescent in Situ Hybridization; Functional disorder; Gene Expression; Genes; Gonadal Steroid Hormones; Habenula; Hormone Receptor; Hormones; Knock-out; Knowledge; Lateral; Lesion; Machine Learning; Mental Depression; Mental disorders; Molecular; Monitor; Motivation; Names; Negative Valence; Neurons; Nuclear Hormone Receptors; Output; Pattern; Positive Valence; Progesterone; Quinine; Research Proposals; Rewards; Rodent; Role; Sex Differences; Signal Transduction; Specificity; Steroids; Stress; Sucrose; Sum; System; Taste Perception; Technology; Testing; Testosterone; Training; Uncertainty; Ventral Tegmental Area; Viral; Work; addiction; base; biological adaptation to stress; calcium indicator; cell type; data resource; depressive symptoms; dorsal raphe nucleus; experimental study; hormonal signals; hormone regulation; insight; male; mental set; mood regulation; motivated behavior; neural circuit; neuropsychiatric disorder; neuropsychiatry; neuroregulation; neurotechnology; new therapeutic target; nonhuman primate; relating to nervous system; response; reward circuitry; reward processing; steroid hormone; steroid hormone receptor; therapeutic target; tool

Project Summary This proposal seeks to investigate sex hormone effects on reward and aversion-related behaviors through mapping of Lateral Habenula (LHb) circuits. The LHb is a central hub important for encoding aversive information and coordinating motivated behaviors, actions critical for survival. Dysfunction in LHb-dependent circuits contribute to a diverse set of disordered behaviors, such as aberrant processing of positive and negative valence, anhedonia, depressive symptomology, and maladaptive stress response, to name a few. While it is known that motivated behaviors are modulated by circulating sex hormones, no studies have investigated whether negative circuit regulators, specifically projections from the LHb, contribute to this phenomenon. Furthermore, nuclear hormone receptors in the brain have not been well characterized, therefore understanding their role within LHb reward circuits and how they interact with circulating hormones will provide insight into mechanisms driving sex hormone effects on reward-related behaviors. In this proposal, by taking advantage of the most recent technologies to define, manipulate, and monitor neural activity, I plan to test the functional contribution of specific hormone receptors on molecularly defined LHb projection neurons on reward and aversion-related behaviors.

项目总结