Evaluation of the guidelines for infection control and prevention, which was made for national university hospitals in Japan

为日本国立大学医院制定的感染控制和预防指南的评估

• 批准号: 13672418
• 负责人: ICHIYAMA Satoshi
• 金额: $ 2.56万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672418/
• 关键词: Hospital Infection; Infection Control Guideline; Centers for Disease Control and Prevention; Surveillance; Infectious Disease Specialist; Infection Conlrol Doctor; Recommendation; Infection Control Team; B型肝炎; 食中毒; 感染経路予防策; カテーテル関連血流感染症; 手術部位感

Head investigator, Satoshi Ichiyama, headed the committee set up to make the guidelines for infection control and prevention for the National University Hospitals in Japan. The guidelines were made with referring the guidelines of Centers of Disease Control and Prevention (CDC) modified to fit the hospitals and were completed at November 2001. The guidelines comprises five parts: Standard precautions and transmission-based precautions; Prevention and control of specific pathogens (I.e., Tuberculosis, Measles, Legionella); Prevention of specific nosocomial infections (I.e., Urinary Tract Infection, Ventilator Associated Pneumonia, Surgical Site Infection); Environmental Infection Control; Others (I.e., Management of Intravascular Catheter-related Infections, Management of Occupational Exposures to HBV, HCV, and HIV). The guidelines were revised at December 2002, and the guideline for food poisoning was addedInfection Control Doctors (ICD), who were specialists for infectious diseases, practiced the infection control based on this guidelines at Kyoto University Hospital. Until December 2002, a total of 636 cases were investigated. Among them, 500 had abnormal laboratory data associated with severe infectious diseases, 98 had consultation to ICD, and 28 had inappropriate use of antibiotics. Appropriate diagnosis and treatment were recommended on 62% and 69% of the cases, respectively, and the diagnosis and treatment were modified according to the recommendations on 56% and 51% among them, respectively. Furthermore, appropriate infection control practices were recommended on 14% of the cases, with 85% modification. In conclusion, many of medical doctors in Japan had only inadequate knowledge of infectious diseases and infection control, therefore, ICD should commit to the diagnosis and treatment of infectious diseases for the compliance of infection control guidelines

首席研究员市山聪(Satoshi Ichiyama)领导了为日本国立大学医院制定感染控制和预防指南的委员会。该指南参考了疾病控制和预防中心(CDC)的指南，并根据医院的需要进行了修改，于2001年11月完成。该指南包括五个部分：标准预防措施和基于传播的预防措施；特定病原体(如结核病、麻疹、军团菌)的预防和控制；特定医院感染的预防(如尿路感染、呼吸机相关性肺炎、手术部位感染)；环境感染控制；其他(如血管内导管相关感染的管理、对乙肝病毒、丙型肝炎病毒和艾滋病毒的职业暴露的管理)。2002年12月对指南进行了修订，增加了食物中毒指南。作为传染病专家的传染病控制医生(ICD)在京都大学医院根据该指南进行了感染控制。截至2002年12月，共调查了636起案件。其中，与严重传染病相关的实验室检查异常500例，咨询ICD的98例，使用抗生素不当的28例。分别有62%和69%的病例推荐了合适的诊断和治疗方案，56%和51%的病例根据推荐修改了诊断和治疗方案。此外，对14%的病例推荐了适当的感染控制措施，85%的病例进行了修改。综上所述，日本的许多医生对传染病和感染控制的知识不够，因此，ICD应该致力于传染病的诊断和治疗，以遵守感染控制指南

项目成果

Yoshitsugu Iinuma: "Evaluation of the BDProbeTec ET System for direct detection of Mycobacterium tuberculosis in Respiratory samples in comparison to the Cobas Amplicor PCR"Eur J Clin Microbiol Infecti Dis. (in press).

Yoshitsugu Iinuma：“与 Cobas Amplicor PCR 相比，对 BDProbeTec ET 系统直接检测呼吸道样本中结核分枝杆菌的评估”Eur J Clin Microbiol Infecti Dis。

Hisashi Baba: "Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity"Infect Immun. 70巻1号. 107-113 (2002)

Hisashi Baba：“缺乏成孔活性的截短肺炎球菌溶血素诱导γ干扰素和一氧化氮” Infect Immun，第 70 卷，第 1. 107-113 期（2002 年）。

Saito,T, Senda,K, Takakura,S, Fujihara,N, Kudo,T, Iinuma,Y, Kiuchi,T, Tanimoto,M, Ichiyama,S: "Biliary bacteria in living related liver transplant recipients: Microbiology and rapid detection system using flow cytometry"Clin Chem Lab Med. 41. 159-163 (200

Saito,T, Senda,K, Takakura,S, Fujihara,N, Kudo,T, Iinuma,Y, Kiuchi,T, Tanimoto,M, Ichiyama,S：“活体相关肝移植受者中的胆道细菌：微生物学和快速检测

Iinuma,Y, Senda,K, Fujihara,N, Saito,T, Takakura,S, Shimojima,M, Kudo,T, Ichiyama,S: "Evaluation of the BDProbeTec ETSystem for direct detection of Mycobacterium tuberculosis in Respiratory samples in comparison to the Cobas Amplicor PCR"Eur J Clin Microb

Iinuma,Y, Senda,K, Fujihara,N, Saito,T, Takakura,S, Shimojima,M, Kudo,T, Ichiyama,S：“评估 BDProbeTec ET 系统直接检测呼吸道样本中结核分枝杆菌的效果，并与

Hisashi Baba: "Induction of gamma interferon and nitric oxide by truncated pneumolysin that lacks pore-forming activity"Infect Immun. 70. 107-113 (2002)

Hisashi Baba：“缺乏成孔活性的截短肺炎球菌溶血素诱导γ干扰素和一氧化氮”感染免疫。