Analysis of unmyelinated nerve fibers in the human mandibular nerve

人下颌神经无髓神经纤维的分析

• 批准号: 13680827
• 负责人: GOTO Noboru
• 金额: $ 1.66万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680827/
• 关键词: Mandibular nerve; Unmyelinated fibers; MyeLinated fibers; Axonal size; Human; Aging process; Morphometry; Image-analyzer; 三叉神経; 軸索

In the year of 2001, the material of the mandibular nerves was removed from the six human corpora with dentulous jaws out of 30 cadavars for anatomic dissections. The age ranged from 26 to 86 years. Nitrocellulose|-embedded tissue sections(25um thick, Masson-Goldner-Goto stain) were prepared after fixation formalin followed by chromic acid solution. Evaluation of nerve fiber axons were made using an image analyzer equipped with a microscope and a drawing tube. Unmyelinated nerve fibers in the human mandibulae nerve showed a decrease in size (area) with age. In the year of 2002, the similar evalutions were made regarding the myelinated nerve fibers on the size with age. This phenomenon can be observed in almost all peripheral nerves. However, the reason why only the unmyelinated fibers of the human mandibular nerve show an increase in size still remains unsolved.

2001年，从30具成人身体的6具下颌骨标本中取出下颌神经材料进行解剖。年龄26~86岁。硝酸纤维素包埋组织切片(25微米厚，Masson-Goldner-Goto染色)，福尔马林固定后，用铬酸溶液固定。用配有显微镜和图像管的图像分析仪对神经纤维轴突进行评价。人下颌神经中无髓神经纤维的大小(面积)随年龄增长而减小。2002年，对有髓神经纤维的大小随年龄的变化也进行了类似的评估。这种现象在几乎所有的周围神经中都可以观察到。然而，为什么只有人类下颌神经的无髓鞘纤维显示出大小增加的原因仍然没有解决。

项目成果

Goto J et al.: "Morphometric differenciation of nerve fibers:Central,peripheral,myelinated and unmyelinated"Okajimas Folia Anat Jpn. 77. 211-216 (2001)

Goto J 等：“神经纤维的形态差异：中枢、外周、有髓鞘和无髓鞘”Okajimas Folia Anat Jpn.

Tani H et al.: "Morphometric analysis of the human tibial nerve and the ageing process"Okajimas Folia Anat Jpn. 78・2/3. 61-64 (2001)

Tani H等：“人类胫神经的形态分析和老化过程”Okajimas Folia Anat Jpn. 78・2/3 (2001)。

Ma X et al.: "Development of the human lateral cuneate nucleus : a morphometric evaluation"Developmental Brain Research. 136. 69-75 (2002)

马X等人：“人类外侧楔形核的发育：形态测量评估”脑发育研究。

He HJ et al.: "Distributions of lesions in hanging suicide brains"Okajimas Folia Anat Jpn. 78・6. 253-258 (2002)

He HJ 等：“自杀者大脑损伤的分布”Okajimas Folia Anat Jpn. 78・6 (2002)。

Ma X et al: "Development of the human gracilis nucleus : A morphometric evaluation"Okajimas Folia Anat Jpn. 78・4. 115-122 (2001)

Ma X 等：“人类股薄核的发育：形态测量评估”Okajimas Folia Anat Jpn. 78・4 (2001)。