Bio-absorbable material for reconstruction of the rotator cuff defect

用于重建肩袖缺损的生物可吸收材料

• 批准号: 13680945
• 负责人: AOKI Mitsuhiro
• 金额: $ 2.05万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680945/
• 关键词: Bio-absorbable materials; Poly-L-lactic acid felt; Culture; Transplantation; Hydrolysis; Reconstruction of rotator cuff; Enthesis; Tensile strength; テフロンフェルト; PDSテープ; 機械特性; 組織反応

Poly(L-lactic acid) felt (PLLA felt) was prepared in an attempt to reconstruct the rotator cuff in beagle dogs. Little change was found on the tensile strength of both the cultured PLLA felt and the PLLA felt implanted on the para-vertebral muscle of rabbits up to 12 weeks, although the stiffness of the felt implanted on the muscle of 6 weeks showed a statistically significant increase. When the infraspinatus tendons of beagle dog were reconstructed with the PLLA felt, the ultimate strength of PLLA felt increased 3 times and the stiffness increased 5 times at 16postoperative weeks compared to that of the PLLA felt. They were statistically significant (p<0.01). All the implanted specimens ruptured at the junction between the bone and the PLLA felt. Histological examination demonstrated infiltration of fibrous tissue into the interstices of the PLLA felt fibers. Connection between the infraspinatus tendon and the PLLA felt was tight under formation of scar tissue, but the connective tissue between the bone and PLLA felt fibers was sparse even at 16 and 32 postoperative weeks. A few deteriorated PLLA felt fibers were observed at 32 postoperative weeks. Although the degradation rate of PLLA felt was very low, the PLLA felt was found to be useful for rotator cuff reconstruction.

制备聚（L-乳酸）毡（PLLA毡），尝试重建比格犬的肩袖。培养的PLLA毡和植入家兔椎旁肌的PLLA毡的拉伸强度在12周内几乎没有变化，尽管植入肌肉的6周毡的刚度显示出统计学显著的增加。用PLLA毡重建Beagle犬冈下肌肌腱，术后16周时，PLLA毡的极限强度比PLLA毡提高了3倍，刚度提高了5倍。两者有统计学意义（p<0.01）。所有植入样本均在骨和PLLA毡之间的连接处破裂。组织学检查表明纤维组织浸润到PLLA毡纤维的间隙中。在瘢痕组织形成下，冈下肌腱和PLLA毡之间的连接紧密，但即使在术后16周和32周，骨和PLLA毡纤维之间的结缔组织也稀疏。术后32周观察到少量PLLA毡纤维退化。尽管PLLA毡的降解率非常低，但发现PLLA毡可用于肩袖重建。

项目成果

Kagaya K, et al: "Initial strength of repaired rotator cuff : immediate repair and delayed repair"Shoulder Joint. 26, (Japanese). 203-206 (2002)

Kagaya K 等人：“修复肩袖的初始强度：立即修复和延迟修复”肩关节。

青木光広ほか: "腱板縫合および再建術の縫合部機械特性"北海道リハビリ. 30. 49-54 (2002)

Mitsuhiro Aoki 等：“肩袖缝合和重建的机械特性”北海道康复。 30. 49-54 (2002)。

Aoki M, et al: "Experimental rotator cuff repair and reconstruction and its relationship to tensile strength"J Hokkaido Rehabilitation Assoc. 30, (Japanese). 49-54 (2002)

Aoki M 等人：“实验性肩袖修复和重建及其与拉伸强度的关系”J Hokkaido Rehabilitation Assoc。

Takiuchi T, et al: "Pull out strength of suture anchor implanted into the greater tuberosity"Shoulder Joint. 26, (Japanese). 477-480 (2002)

Takiuchi T 等人：“植入大结节的缝合锚钉的拉力”肩关节。

木村明彦, ほか: "PTFE feltの骨溝内移植に伴う組織反応と材料の劣化:偏光および暗視野顕微鏡像による観察"肩関節. 27(掲載予定). (2003)

Akihiko Kimura 等人：“与将 PTFE 毡植入骨槽相关的组织反应和材料退化：使用偏振光和暗视野显微镜图像进行观察”27（即将出版）。