Bio-absorbable material for reconstruction of the rotator cuff defect

用于重建肩袖缺损的生物可吸收材料

• 批准号: 13680945
• 负责人: AOKI Mitsuhiro
• 金额: $ 2.05万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680945/
• 关键词: Bio-absorbable materials; Poly-L-lactic acid felt; Culture; Transplantation; Hydrolysis; Reconstruction of rotator cuff; Enthesis; Tensile strength; テフロンフェルト; PDSテープ; 機械特性; 組織反応

Poly(L-lactic acid) felt (PLLA felt) was prepared in an attempt to reconstruct the rotator cuff in beagle dogs. Little change was found on the tensile strength of both the cultured PLLA felt and the PLLA felt implanted on the para-vertebral muscle of rabbits up to 12 weeks, although the stiffness of the felt implanted on the muscle of 6 weeks showed a statistically significant increase. When the infraspinatus tendons of beagle dog were reconstructed with the PLLA felt, the ultimate strength of PLLA felt increased 3 times and the stiffness increased 5 times at 16postoperative weeks compared to that of the PLLA felt. They were statistically significant (p<0.01). All the implanted specimens ruptured at the junction between the bone and the PLLA felt. Histological examination demonstrated infiltration of fibrous tissue into the interstices of the PLLA felt fibers. Connection between the infraspinatus tendon and the PLLA felt was tight under formation of scar tissue, but the connective tissue between the bone and PLLA felt fibers was sparse even at 16 and 32 postoperative weeks. A few deteriorated PLLA felt fibers were observed at 32 postoperative weeks. Although the degradation rate of PLLA felt was very low, the PLLA felt was found to be useful for rotator cuff reconstruction.

制备了聚（L-乳酸）毛毡（PLLA毛毡），以试图重建Beagle犬中的肩袖。培养的PLLA毛毡的拉伸强度几乎没有变化，尽管植入了6周的肌肉植入的毛毡的僵硬表现出统计学意义的显着增加，但在长达12周的兔子骨骼肌肉上植入了PLLA。当将Beagle狗的肌腱与PLLA毛毡重建时，PLLA的最终强度感觉到了3次，并且与PLLA的感觉相比，刚度在16次术时的刚度增加了5倍。它们具有统计学意义（p <0.01）。所有植入的标本在骨头和PLLA之间的连接处破裂。组织学检查表明，纤维组织渗入PLLA毛毡纤维的间隙。在疤痕组织的形成下，肌腱和PLLA感觉之间的联系紧密，但是即使在术后16和32周，骨头和PLLA之间的结缔组织也很稀疏。在术后32周观察到一些恶化的PLLA毡纤维。尽管PLLA感觉的降解速率非常低，但发现PLLA被发现对肩袖重建有用。

项目成果

Kagaya K, et al: "Initial strength of repaired rotator cuff : immediate repair and delayed repair"Shoulder Joint. 26, (Japanese). 203-206 (2002)

Kagaya K 等人：“修复肩袖的初始强度：立即修复和延迟修复”肩关节。

青木光広ほか: "腱板縫合および再建術の縫合部機械特性"北海道リハビリ. 30. 49-54 (2002)

Mitsuhiro Aoki 等：“肩袖缝合和重建的机械特性”北海道康复。 30. 49-54 (2002)。

Aoki M, et al: "Experimental rotator cuff repair and reconstruction and its relationship to tensile strength"J Hokkaido Rehabilitation Assoc. 30, (Japanese). 49-54 (2002)

Aoki M 等人：“实验性肩袖修复和重建及其与拉伸强度的关系”J Hokkaido Rehabilitation Assoc。

木村明彦, ほか: "PTFE feltの骨溝内移植に伴う組織反応と材料の劣化:偏光および暗視野顕微鏡像による観察"肩関節. 27(掲載予定). (2003)

Akihiko Kimura 等人：“与将 PTFE 毡植入骨槽相关的组织反应和材料退化：使用偏振光和暗视野显微镜图像进行观察”27（即将出版）。

Takiuchi T, et al: "Pull out strength of suture anchor implanted into the greater tuberosity"Shoulder Joint. 26, (Japanese). 477-480 (2002)

Takiuchi T 等人：“植入大结节的缝合锚钉的拉力”肩关节。