The elucidation of the pathophysiology of Meniere's disease induced by the circadian rhythm disorder

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Intractable cases with Meniere's disease often show a disorder of circadian rhythm because of repeated vertigo attacks and severe tinnitus. In mouse model of Meniere's disease by chronic administration of arginin-vasopressin (AVP), the significant disorder of the circadian rhythm in the locomotion test was found in comparison with the control mouse by chronic administration of normal saline. In addition, the threshold in auditory brainstem response significantly increased during 2 weeks of administration of AVP. Our results suggest that the elevation of AVP in intractable cases with Meniere's disease induces the disorder of the circadian rhythm, resulting in affecting the prognosis of Meniere's disease.