Study on Rheolpgy of Flowing Blood in narrou metal chanel

狭窄金属通道内血液流动流变学的研究

• 批准号: 13680952
• 负责人: KANAI Naoaki
• 金额: $ 2.05万
• 依托单位: TOKAI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680952/
• 关键词: hemorheology; platelet; thrombus; 医療用極細金属細管; シリコンスリット; 健康診断; マイクロサージェリー; 動脈硬化

We made 2 studies on rheology of flowing blood in narrow matal chanels as belowl)Evaluation of Blood Fluidity by Means of MC-FAN and the Effects of Japanese apricot Extracts on Blood FluidityHeparin containing blood fluidity was evaluated in terms of passage timej on MC-FAN. Since fluctuation of each individual passage time reflected thedifference of platelet coagulating ability amongindividuals, we can ignoreif we analyzed blood within 10 min after collection without application ofshear stress. For twelve volunteers (9 male, 3 female; from 22 yrs old to 60 yrs old) of healthy adult,passage time of whole blood of 2000 μl was evaluated at the time of pre and post administration of Japanese apricot extracts for one month; l)for the blood to show high ability of coagulation, the extractsmake more endurance to physical stress, 2)for the blood withoutcoagulation but tended to be high viscosity, the extracts make blood less viscosity, 3)for the blood without coagulation and tended to be low viscosity, the plum extracts make it to be higher, 4)passage time tended to be converged to the total average passage time. These findings suggested that the long term administration of Japanese apricot extracts resulted in blood fluidity to be kept in homeostatic state.2)Development and assessment of a new clinical laboratory test method in anti-thrombotic therapy Most of patients suffer from artriosclerosis obliterans are forced to take anti-thrombotic drugs. However, it is very hard toknow proper doses, because it's reliable guide has not yet been defined. In this study, we made a blood-flow channel based on phathophsiology, and developed a system for visualizing the process of thrombus formation. As the results of the experiment using this system, thrombi due to platelets were observed at the blood without anti-thrombotic drugs. On the other hand,the formation of thrombus was not observed at for the blood with the drugs.

本文对狭窄金属通道内流动血液的流变学进行了两项研究：（1）用MC-FAN评价血液流动性及日本杏提取物对血液流动性的影响。由于每个个体的通过时间的波动反映了个体间血小板聚集能力的差异，因此，如果在采集后10分钟内不施加剪切力进行分析，则可以进行重新分析。12志愿者健康成年人（9男3女，年龄22 - 60岁），在日本杏提取物给药前和给药后1个月评价2000 μl全血的传代时间; 1）对于具有高凝能力的血液，提取物对物理应激的耐受性更强; 2）对于不凝但粘度更高的血液，各提取物使血液粘度降低; 3）对于无凝血倾向的低粘度血液，李子提取物使其粘度升高; 4）通过时间趋于收敛于总平均通过时间。这些结果表明，长期服用日本杏提取物可使血液流动性保持在稳态。2）抗血栓治疗中新的临床实验室检测方法的开发和评价大多数闭塞性动脉炎患者被迫服用抗血栓药物。然而，很难知道合适的剂量，因为它的可靠指南尚未确定。在本研究中，我们根据血栓形成的生理学原理制作了一个血流通道，并开发了一个可视化血栓形成过程的系统。作为使用该系统的实验的结果，在没有抗血栓形成药物的血液中观察到由于血小板引起的血栓。另一方面，对于含有药物的血液，未观察到血栓形成。