Epidemiologic studies on the screening for sleep disordered breathing in relation to cardiovascular diseases.

睡眠呼吸障碍（SDB）是一种在睡眠期间反复发作的呼吸气流减少或停止的状况。我们已经进行了几次调查，使用脉搏血氧仪检测SDB在工作人群和社区。我们发现日本男性居民和工人中SDB的患病率与美国和欧盟国家相似。为了研究SDB与日本男性血压水平的关系，我们在农村和城市社区男性中进行了一项基于人群的横断面研究。选择3%氧减饱和指数（ODI）作为SDB的指标。ODI水平3%的低与高类别的高血压的多变量比值比为1.63（95%CI，1.1-2.5）。这些关联在超重者中比非超重者更明显。此外，我们还通过夜间脉搏血氧仪测量了日本核电站男性轮班工人和男性日工的ODI。校正潜在混杂变量后，总受试者的收缩压和舒张压水平与3%ODI显著相关（p=0.04）。这种关联主要在年龄[大于或等于]40岁的工人中观察到，更具体地说，是老年轮班工人。SDB严重程度和舒张压水平之间的相关性，年龄大于或等于40岁的轮班工人之间的提示SDB筛查轮班工人的血压控制的重要性。为了阐明平时饮酒和夜间氧饱和度下降之间的关系，我们比较了ODI水平根据酒精摄入量的类别。我们发现，在日本中年男性中，饮酒量和SDB的严重程度之间存在显著的正相关，与年龄、BMI和吸烟无关。这种关联在非超重受试者中更为明显，表明戒酒对非超重SDB患者的重要性。

Sleep-disordered breathing (SDB) is a condition of repetitive episodes of decreased or arrested respiratory airflow during sleep. We have conducted several surveys using the pulse-oximetry to detect SDB in working populations and communities. We found that prevalence of SDB among male residents and workers in Japan was similar to that in the US and EU countries.To examine the relationship between SDB and blood pressure levels among Japanese men, we conducted a population-based cross-sectional study in rural and urban communities men. The 3% oxygen desaturation index (ODI) was selected as the indicator of SDB. The multivariate odds ratio of hypertension for the low versus high category of 3% ODI level was 1.63 (95% CI, 1.1-2.5). These associations were more evident among overweight than non-overweight individuals. In addition, we measured ODI by nocturnal pulse-oximetry among male shift workers and male day workers at nuclear power plants in Japan. Systolic and diastolic blood pressure levels were significantly correlated with 3%ODI in total subjects after adjustment for potential confounding variables (p=0.04). This association was primarily observed among workers aged 【greater than or equal】40 years, more specifically older shift workers. A correlation between SDB severity and diastolic blood pressure levels among shift workers aged 【greater than or equal】40 years suggests the importance of screening for SDB among shift workers for blood pressure control.To clarify the association between usual alcohol consumption and nocturnal oxygen desaturation, we compared ODI levels according to categories of alcohol intake. We found a significant positive association between usual alcohol consumption and the severity of SDB among middle-aged Japanese men, independent of age, BMI and smoking. This association was more evident among non-overweight subjects, indicating the importance of alcohol abstinence for non-overweight SDB patients.