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Development of new prostheses for arthroplasty with an added ability to promote bone repair using bone morphogenetic protein (BMP)

开发用于关节成形术的新型假体，并具有使用骨形态发生蛋白 (BMP) 促进骨修复的附加能力

基本信息

批准号：
14370459
负责人：
SAITO Naoto
金额：
$ 8.77万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

项目摘要

In order to developing new prostheses for arthroplasty with an added ability to promote bone repair using bone morphogenetic protein (BMP), we first developed a safe new BMP delivery system using PLA-DX-PEG, a biodegradable polymer. This polymer is suitable for incorporating BMP and constructing a prosthetic device. The prosthesis constructed from this BMP/PLA-DX-PEG composite was then used for experimental hip replacement in an animal model to confirm the usefulness of this device. However, many problems related to BMP itself remain to be resolved before clinical application of this prosthesis containing BMP. In humans, insufficient bone formation is obtained with small volumes of BMP, which makes a large quantity of BMP necessary. However, BMP is expensive. To resolve this problem, we studied the application of PTH or pentoxifylline, either of which can improve the bone induction ability of BMP. Next, we tried bone marrow mononuclear cell transplantation to improve blood flow in tissue surrounding the area undergoing bone repair. The new prosthetic material that we developed showed a high affinity to bone, and a potent ability to improve bone repair using BMP. The compositions of conventional prosthetic materials and this new material are currently being studied in order for this new material to be effectively incorporated into a prosthesis containing BMP. From improving the ability of BMP to promote bone repair to the development of new materials to construct the prosthesis, we developed a general technology for new prostheses for arthroplasty with an added ability to promote bone repair using BMP. We consider it necessary to promote more multidirectional approaches to the clinical application of BMP.

为了开发具有骨形态发生蛋白(BMP)促进骨修复能力的新型关节置换假体，我们首先开发了一种使用可生物降解聚合物聚乳酸-DX-聚乙二醇的安全的新型BMP给药系统。该聚合物适用于骨形态发生蛋白的包埋和假体的构建。用这种骨形态发生蛋白/聚乳酸-DX-聚乙二醇复合材料构建的假体随后被用于动物模型的实验性髋关节置换，以证实该装置的有效性。然而，在这种含有BMP的假体临床应用之前，与BMP本身相关的许多问题仍有待解决。在人类中，少量的BMP不能获得足够的骨形成，这就需要大量的BMP。然而，BMP是昂贵的。为了解决这一问题，我们研究了PTH或己酮可可碱的应用，这两种方法都可以提高BMP的成骨能力。接下来，我们尝试了骨髓单个核细胞移植，以改善骨修复区域周围组织的血液流动。我们开发的新型假体材料表现出对骨的高亲和力，并具有利用BMP促进骨修复的强大能力。目前正在研究传统假体材料和这种新材料的组成，以便将这种新材料有效地结合到含有BMP的假体中。从提高BMP促进骨修复的能力到开发新材料来构建假体，我们开发了一种通用的关节置换新假体技术，并增加了使用BMP促进骨修复的能力。我们认为有必要推广更多的多向方法来应用BMP的临床应用。