权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A role of monkey perirhinal cortex in relational memory and learning

猴子鼻周皮层在关系记忆和学习中的作用

基本信息

批准号：
14510115
负责人：
YUKIE Masao
金额：
$ 2.11万
依托单位：
Tokyo Metropolitan Organization for Medical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14510115/
关键词：
delayed matching-to-sample task a small set of stimuli a large set of stimuli transverse patterning task relational association configural association perirhinal cortex hippocampus ニホンザル同時複式視覚弁別学習 Transverse Patterning Problem 要素連合

项目摘要

To clarify roles of perirhinal cortex in memory and learning, especially in relational or configural ones, effects of perirhinal cortex lesion on delayed matching-to-sample tasks (DMS) with small (3 stimuli) and large (300 stimuli) sets of stimuli (DMS-S and DMS-L, respectively) and transverse patterning task (TPT) were examined using 6 macaque monkeys. Preoperatively, monkeys were trained on DMS-L and DMS-S. Postoperatively, DMS-S was first tested. Thereafter, DMS-L was given to the monkeys. Last, TPT and its control task, concurrent discrimination task (CDT), were trained. As a result, no impairment was seen in relearning of DMS-S or DMS-L or in their delay tests with 30, 60 and 120 sec. Perirhinal cortex lesion, however, produced a severe impairment in transverse patterning task without impairment in CDT. Our monkeys with perirhinal cortex lesion were not impaired in this task, despite that It is well-established that perirhinal cortex is critically involved in DMS-L. It might be possible that they resolved DMS-L by using their learned DMS-S strategy which remained intact.The present results are sharply contrasted with our previous study demonstrating that monkey brain ischemia, which caused cell loss in the hippocampus, produced impairment in DMS-S, but not in DMS-L, TPT or CDT. It has been controversial whether TPT should be regarded as a configural task or as a relational one. However, perirhinal cortex lesion did not impair in DMS-S which might be regarded as a relational task, but in TPT. Thus, the present study suggests that perirhinal cortex might be involved in configural association, but not in relational association.

为了阐明大脑周围皮质在记忆和学习中的作用，特别是在关系型和配置型记忆学习中的作用，用6只猕猴研究了皮层损毁对小(3个刺激)和大(300个刺激)延迟匹配样本任务(S延迟匹配任务和L延迟匹配样本任务)和横向模式匹配任务的影响。术前对猕猴进行DMS-L和DMS-S训练。术后，首先对DMS-S进行测试。此后，给猴子服用了二甲基硫-L。最后对TPT及其控制任务--并发辨别任务(CDT)进行了训练。结果表明，S组和L组的再学习以及30、60和120秒的延迟实验均未见损伤。然而，损毁裂孔周围皮质可严重损害横向构图任务，而不损害CDT。我们的猴子在这项任务中没有受到周边皮质损害的损害，尽管众所周知，周边皮质在DMS-L中起着关键的作用。目前的研究结果与我们以前的研究结果形成鲜明对比，即猴脑缺血导致海马区细胞丢失，导致海马区S受损，而L区、延髓核区和海马区则无损伤。TPT是一种配置性任务，还是一种关系型任务，一直存在争议。然而，在DMS-S任务中，大脑周围皮质损害并没有受到损害，而在TPT中却受到了损害。因此，本研究表明，大脑周围皮质可能参与了结构联想，而不是关系联想。