摺動面被覆率による人工関節摺動面の機械的物性変化の解明と最適設計への適用

阐明人工关节滑动表面机械性能随滑动表面覆盖率的变化以及应用于优化设计

• 批准号: 03J08395
• 负责人: 益田 泰輔
• 金额: $ 1.73万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03J08395/
• 关键词: 関節潤滑; トライボロジー; 生体適合材料; インテリジェント材料; 蛋白吸着

これまでに,Metal-on-Metal人工関節摺動面に対して摺動面被覆率というパラメータを提案し,被覆率による人工関節摺動面の耐摩耗性を求めてきた.そこで昨年度までに,被覆率がMetal-on-Metal人工関節摺動面に形成された酸化膜や吸着分子膜の再形成に大きく影響を及ぼすパラメータであり,人工関節摺動材が潜在的に保有する耐摩耗性を最大限に活用する可能性を示唆することができた.その原因として,(1)被覆率が酸化膜層の硬化や加工変質層の塑性変形を左右すること,あるいは(2)摺動面被覆部において関節液成分(主に蛋白成分)による境界潤滑性の向上し,耐摩耗に寄与することを示唆した.そこで本年度は,蛋白成分が摺動面に吸着し耐摩耗に寄与することを明らかにするために,潤滑液中の蛋白質をリアルタイムで定量し摺動面への吸着量を見積もる方法の構築を目指した.その結果以下のことを明らかにした.1)臨床用屈折計を用いることにより,簡便に関節液中の蛋白濃度を定量でき,リアルタイムに吸着量を見積もることが可能となった.2)関節液中の蛋白濃度は,経時的に低下することを示し,高被覆率においては蛋白濃度低下への遷移期の促進されることが明らかになった.総括として,昨今の組織工学・再生医工学の発達により,将来的に関節疾患は根治することが考えられる.人工関節は根治療法が確立されるまでのBridge-Use(橋渡し的対処療法)と捉えることができる以上,その開発は,最小の時間的・費用的投資とするべきである.摺動面被覆率は,新素材の開発ではなく,臨床使用されている人工関節摺動材料が潜在的に保有している耐摩耗性を新たな知見から最大限に活用するものであり,必要不可欠な技術となりうる,また,被覆率を人工関節へ適用するに当たって,最適な数値を示すには至らなかったが,人工股関節設計における被覆率の導入は,人工股関節の潤滑のみならずトライボロジーの分野に一石を投じるものとなった.

The coverage rate of the folded surface is different from that of the Metal-on-Metal artificial surface, and the wear resistance of the folded surface is determined by the rate of coverage. Last year, the coverage rate of Metal-on-Metal artificial folded surface formed, acidified film, absorbed molecular membrane, and then formed a large film. Artificial folding material has the potential to retain the maximum value of friction resistance and the possibility of active use. The reason is that: (1) the coating rate, acidizing film, hardening, processing, plasticity, plastic, and so on. This year, the protein ingredient folded noodles were sent to you with the absorption of anti-friction and anti-friction, while the protein in the synovial fluid was measured by the method of absorption. The results show that the following results show that the content of protein in the stool is measured quantitatively, and that the absorption of protein in the solution may be sensitive. 2) the protein concentration in the solution is low, and the protein concentration in the solution is low. High coverage rate, low protein level, low protein level, high coverage rate, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein level, high coverage rate, low protein level, low protein content, low protein content, In addition, yesterday and today we organized the organization of engineering, regenerative medicine and engineering, which will lead to a radical cure for diseases and diseases in the future. The manual cure method is to make sure that the Bridge-Use (ferry service method) should be used in the minimum operating time. The covering rate of the folding surface is very high, the new material is open for use, and the machine is used to manually fold the material. It is possible to retain the potential wear resistance of the new material. The maximum limit is not available. If necessary, it is necessary to pay attention to the technical equipment. The coverage rate is very high. The coverage rate of artificial stocks is high, while that of artificial stocks is higher than that of others.