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VALIDATION OF NON-INVASIVE CARDIOVASCULAR MONITORING SYSTEM MAKING USE Of THE TECHNOLOGY TO REALIZE THE ENVIRONMENT OF INNER HUMAN BODY AT OUTSIDE HUMAN BODY

利用该技术在体外实现人体内部环境的无创心血管监测系统的验证

基本信息

批准号：
15360120
负责人：
KANEKO Shigehiko
金额：
$ 9.86万
依托单位：
THE UNIVERSITY OF TOKYO
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

This study is concerned with the validation of recently developed three kinds of typical blood pressure measurement methods such as oscillometric auto blood pressure meter, wristwatch type blood pressure meter utilizing pulse wave traveling time and photoelectric pulse wave monitor to observe blood pressure over 24 hours. We mainly focused on the relation between pulse wave traveling time and the accuracy of actual blood pressure of human body. Therefore, we took account of the effect of boundary condition simulating real situation of human blood pressure measurement.First, we designed and machined an equipment to simulate precisely the behavior of the pressure pulsation and the vibration characteristics of blood vessel of an upper arm of a human body during blood pressure measurement which consists of flexible tube, piston-crank mechanism for driving pulse wave and head tank to maintain average blood pressure. Secondly, we measured various types of pulse waveform by changing resistance of a flexible tube and constrictions. Simultaneously, we developed computer code to simulate the behavior of the blood vessel precisely based on the physical model of the collapsible tube taking account of the effect of rigidity of the tube and boundary conditions. Validity of our program was checked by experimental data using silicon tube. Then, we applied this program to human blood vessels and we first succeeded in obtaining reasonable results which can explain the trend of measured results with human arteries.Furthermore, we succeeded in formulating the method of calculation concerned with fluid structure interaction between thin flexible structure and the flowing fluid where non-linearity of the fluid force is important, which gives us the physical interpretation of the role of nonlinearity in this problem.

本研究对近年来发展起来的三种典型的血压测量方法进行了验证，即自动血压计、利用脉搏波传播时间的手表式血压计和光电脉搏波监测仪，并对这三种血压测量方法进行了24小时以上的血压监测。主要研究了脉搏波传播时间与人体实际血压测量精度的关系。为此，我们考虑了边界条件对模拟人体血压测量真实的情况的影响。首先，我们设计并加工了一台由柔性管组成的精确模拟人体上臂血压测量时的压力脉动行为和血管振动特性的装置，用于驱动脉搏波的活塞曲柄机构和用于维持平均血压的头部罐。其次，我们通过改变软管的阻力和收缩来测量各种类型的脉搏波形。同时，我们开发了计算机程序来精确地模拟血管的行为的基础上的可折叠管的物理模型，考虑到管的刚度和边界条件的影响。用硅管实验数据验证了程序的有效性。然后，将该程序应用于人体血管，首次成功地得到了合理的结果，解释了人体动脉测量结果的变化趋势，并成功地建立了考虑流体力非线性的薄柔性结构与流动流体之间的流固相互作用的计算方法，这给了我们非线性在这个问题中的作用的物理解释。