Molecular mechanism for memory B cell dynamics and survival

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Chemotactic chemokines play important role in the selective recruitment of B cells to different histological tissues, establishing B cell homeostasis and immune response. Here we report that CC chemokine receptor D6 and CCR1 is differentially expressed on MZ and memory B cells in the spleen and B1 cells in the peritoneal cavity. In agreement with previous observations, D6 on B cell subsets physically interact with its ligands, internalize, and target them intracellular degradation, whereasa it did not cause activation of MZ B cells and B1 cells, such as proliferation, terminal differentiation. The results suggest that the genuine function of D6 on B cell subsets is to eliminate CC chemokines from microenvironment surrounding MZ B cell and B1 cells. In addition, during the course of search for memory B cells' specific genes, we have identified the gene 3940 who express at high levels in memory cells and marginal zone B cells. Over expression of 3940 in B cell lymphoma cell lines resulted in the prolongation of cell survival under the pro-apoptoic conditions, suggesting that 3940 may play some role in survival of memory B cells.