Morphological and functional neuroimaging studies on progressive changes in schizophrenia.

关于精神分裂症进行性变化的形态学和功能神经影像学研究。

• 批准号: 15390348
• 负责人: OKUBO Yoshiro
• 金额: $ 8.9万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390348/
• 关键词: schizophrenia; PET; MRI・VBM; fMRI; Neurotropic factors; Peripheral benzodiazepine receptor; 末梢性ベンゾジアゼピン受容体

Using both morphological and functional neuroimaging techniques, we aimed to elucidate the progressive changes in the brain of patients with schizophrenia. One hundred twenty patients with schizophrenia aged 20 to 49 years, 60 males and 60 females, and 120 age and gender matched healthy controls were examined by magnetic resonance imaging(MRI). Voxel-based morphometry revealed that age-related decline in the brain morphology was larger in the patient group than in the control groups. This indicates the existence of progressive neuropathology in schizophrenia. Further, the difference in the brain morphology between the patient group and the control group were more prominent in male than in female. Thus, future research should take gender difference into account. Positron emission tomography with [11C[DAA1106 makes it possible to evaluate peripheral benzodiazepine receptors which reflect activated microglia and gliosis in the living human brain. We conducted [11C[DAA1106 PET study in a preliminary sample of patients with schizophrenia and controls. However, there was no statistical difference between groups.

利用形态学和功能神经影像学技术，我们旨在阐明精神分裂症患者大脑的进行性变化。对120例精神分裂症患者进行了磁共振成像（MRI）检查，年龄20 ~ 49岁，男60例，女60例，并与120例年龄和性别相匹配的健康对照组进行了比较。基于体素的形态测量显示，患者组与年龄相关的脑形态学下降比对照组更大。这表明精神分裂症存在进行性神经病理学。此外，患者组与对照组之间的脑形态差异在男性中比在女性中更显著。因此，未来的研究应考虑性别差异。使用[11 C][DAA 1106的正电子发射断层扫描可以评价外周苯二氮卓类受体，这些受体反映了活人脑中活化的小胶质细胞和胶质增生。我们在精神分裂症患者和对照组的初步样本中进行了[11 C][DAA 1106] PET研究。然而，组间无统计学差异。

项目成果

Language Processing and Human Voice Perception in Schizophrenia : An fMRI study

精神分裂症的语言处理和人类声音感知：一项功能磁共振成像研究

• 发表时间: 2006
• 期刊: Biol Psychiatry 59・10
• 作者: Koeda M;Takahashi H;Yahata N;Matsuura M;Asai K;Okubo Y;Tanaka H
• 通讯作者: Tanaka H

[11C]PE21 : a highly selective radioligand for PET examination of the dopamine transporter in monkey and human brain

[11C]PE21：一种高选择性放射性配体，用于猴和人脑中多巴胺转运蛋白的 PET 检查

• 发表时间: 2003
• 期刊: Eur J Nucl Med Mol Imaging 30
• 作者: Halldin C;Erixon-Lindroth N;Pauli S;Chou YH;Okubo Y;et al.
• 通讯作者: et al.

Men and women show distinct brain activations during imagery of sexual and emotional infidelity

• DOI: 10.1016/j.neuroimage.2006.05.049
• 发表时间: 2006-09
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Hidehiko Takahashi;M. Matsuura;N. Yahata;M. Koeda;T. Suhara;Y. Okubo

Abnormal inter-regional relation of dopamine D2 receptor binding in schizophrenia.

精神分裂症中多巴胺 D2 受体结合的异常区域间关系。

• 发表时间: 2005
• 期刊: Psychiatry Res 138
• 作者: Takada Y.;Kohno R.;Himukai T.;Kamimura S.;Ishibashi K.;Kanai T;Keiichiro Inui;Yasuno F.et al.
• 通讯作者: Yasuno F.et al.

Magnetic brain activity elicited by visually presented symbols and Japanese characters

• DOI: 10.1097/00001756-200404090-00006
• 发表时间: 2004-04
• 期刊: NeuroReport
• 影响因子: 1.7
• 作者: Y. Shirahama;K. Ohta;A. Takashima;E. Matsushima;Y. Okubo