Brain functional imaging study of possible effects of substance Preceptor antagonist on alcohol craving

物质受体拮抗剂对酒精渴望可能影响的脑功能成像研究

• 批准号: 22659212
• 负责人: OKUBO Yoshiro
• 金额: $ 2.1万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659212/
• 关键词: アルコール依存症; サブスタンス P 受容体; 脳機能画像; サブスタンスＰ; 薬物依存; アルコール依存; fMRI; サブスタンスP受容体

Neurokinin-1 (NK1) receptor, the cognate receptor for substance P (SP), is highly expressed in the nucleus accumbens (NAc) and has been hypothesized to have a role in positive reward processing in the NAc in humans. Therefore, we conducted a functional MRI (fMRI) study to assess the effects of an NK1 receptor antagonist on human reward processing. Healthy adults participated in series of an fMRI study, taking either a placebo or the NK1 receptor antagonist aprepitant. fMRI showed significant decrease in blood oxygenation-level-dependent signals in the NAc during gain anticipation with the aprepitant treatment compared to the placebo treatment. These results suggest that SP/NK1 receptor system is involved in reword processing and plays a role in accentuating positive valence or alcohol craving in the reward circuit.

神经激肽-1（NK 1）受体是P物质（SP）的同源受体，在人的丘脑核（NAc）中高度表达，并被假设在人类NAc的正性奖赏加工中发挥作用。因此，我们进行了功能性MRI（fMRI）研究，以评估NK 1受体拮抗剂对人类奖励处理的影响。健康成年人参加了一系列功能磁共振成像研究，服用安慰剂或NK 1受体拮抗剂阿瑞匹坦。fMRI显示，与安慰剂治疗相比，阿瑞匹坦治疗在增益预期期间NAc中的血氧水平依赖性信号显著降低。这些结果表明，SP/NK 1受体系统参与了复述加工，并在奖赏回路中起着加重正效价或酒精渴求的作用。

项目成果

講演紹介「PETを用いた新規抗精神病薬blonanserinの評価」

讲座简介：《利用PET评价新型抗精神病药布南色林》

• 发表时间: 2011
• 期刊: 臨床精神薬理
• 作者: Abe-Mukumoto S;Mori T;Sakabe JI;Fukamachi S;Nakamura M;Kabashima K;Tokura Y;舘野周
• 通讯作者: 舘野周

Effect of caffeine and placebo on cerebral response to vocal emotional sounds and working memoryy:An fMRI study

咖啡因和安慰剂对大脑对声音情绪声音和工作记忆的反应的影响：功能磁共振成像研究

• 发表时间: 2011
• 作者: Koeda M;Nakano Y;Ikeda Y;Tateno A;Kim WC;Takahashi H;Suzuki H;Matsuura M;Okubo Y
• 通讯作者: Okubo Y

Paliperidone徐放錠の脳内動態特性

帕潘立酮缓释片的脑动力学特征

• 发表时间: 2011
• 作者: 花元克巳;川辺睦;迫田晃弘;片岡隆浩;岡田麻里;山岡聖典;大久保善朗
• 通讯作者: 大久保善朗

Influence of contact with schizophrenia on implicit attitudes towards schizophrenia patients held by clinical residents.

• DOI: 10.1186/1471-244x-12-205
• 发表时间: 2012-11-22
• 期刊: BMC psychiatry
• 影响因子: 4.4
• 作者: Omori A;Tateno A;Ideno T;Takahashi H;Kawashima Y;Takemura K;Okubo Y
• 通讯作者: Okubo Y

Cerebral activation associated with speech sound discrimination during the diotic listening task: An fMRI study

• DOI: 10.1016/j.neures.2010.02.006
• 发表时间: 2010-05
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Y. Ikeda;N. Yahata;Hidehiko Takahashi;M. Koeda;K. Asai;Y. Okubo;Hidenori Suzuki