Brain functional imaging study of possible effects of substance Preceptor antagonist on alcohol craving

神经激肽-1(NK1)受体是P物质(SP)的同源受体，在人的伏隔核(NAC)中高表达，并被认为在NAC的正向奖赏加工中起作用。因此，我们进行了一项功能磁共振成像(FMRI)研究，以评估NK1受体拮抗剂对人类奖赏加工的影响。健康的成年人参加了一系列的功能磁共振研究，服用安慰剂或NK1受体拮抗剂。功能磁共振成像显示，与安慰剂治疗相比，与安慰剂治疗相比，在预期恢复期间，NAC中的血氧水平依赖信号显著减少。这些结果表明，SP/NK1受体系统参与了重词加工，并在奖赏环路中起到加强正价或酒精渴求的作用。

Neurokinin-1 (NK1) receptor, the cognate receptor for substance P (SP), is highly expressed in the nucleus accumbens (NAc) and has been hypothesized to have a role in positive reward processing in the NAc in humans. Therefore, we conducted a functional MRI (fMRI) study to assess the effects of an NK1 receptor antagonist on human reward processing. Healthy adults participated in series of an fMRI study, taking either a placebo or the NK1 receptor antagonist aprepitant. fMRI showed significant decrease in blood oxygenation-level-dependent signals in the NAc during gain anticipation with the aprepitant treatment compared to the placebo treatment. These results suggest that SP/NK1 receptor system is involved in reword processing and plays a role in accentuating positive valence or alcohol craving in the reward circuit.