Effects of static magnetic field given by the iron-platinum magnet alloy on osteoanagenesis

铁铂磁体合金静磁场对成骨作用的影响

• 批准号: 15390584
• 负责人: TAKADA Yukyo
• 金额: $ 7.81万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390584/
• 关键词: Iron-platinum magnet alloy; Osteogenesis; Ca; P; In vivo; Biomedical stainless steel; Elution test; Rat; static magnetic field; 白金鉄磁石; 静磁場; 骨組織; 動物実験; チタン; 骨誘導; ウサギ; 歯科用磁性アタッチメント

This research pertains to animal trials examining the bio-compatibility and bone-compatibility of magnetic platinum-iron. Non-magnetic and magnetic platinum-iron, titanium, and stainless steel were implanted into the tibial of rats between 1 and 12 weeks. Furthermore, bone growth speed, bone maturation and bone growth quantity were analyzed and the influence of the static magnetic field on osteogenesis was studied. The findings were that titanium, non-magnetic and magnetic platinum iron did not affect the histopathology, the distribution of Ca and P in the areas surrounding the Implant. What is more, over time the Ca/P index and cells growth quantity showed no statistical change. From this experiment, according to the static magnetic field, osteogenesis was not proven. However, there was no in vivo damage by the static magnetic field, but compared to stainless steel bone growth quantity was significant. From these findings, non-magnetic and magnetic platinum-iron were the same as titanium on bone maturation and bone growth, excelling at bio-compatibility and bone-compatibility, in turn suggesting the safe use of magnetic alloy in vivo.

本研究涉及磁性铂铁的生物相容性和骨相容性的动物试验。在1 ~ 12周大鼠胫骨内植入非磁性和磁性铂铁、钛和不锈钢。分析了骨生长速度、骨成熟度和骨生长量，研究了静磁场对成骨的影响。结果表明，钛、非磁性和磁性铂铁均不影响种植体周围组织病理学和钙、磷的分布。Ca/P指数和细胞生长量随时间变化无统计学意义。从这个实验来看，根据静态磁场，成骨并没有得到证实。然而，静磁场对体内无损伤，但与不锈钢相比骨生长量显著。由此可见，非磁性和磁性铂铁在骨成熟和骨生长方面与钛相同，具有良好的生物相容性和骨相容性，从而提示磁性合金在体内的安全使用。