Development of the bioactive titanium alloy equipped with an osteoinductive property

具有骨诱导特性的生物活性钛合金的开发

• 批准号: 21390523
• 负责人: TAKADA Yukyo
• 金额: $ 11.4万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390523/
• 关键词: チタン合金; Mg 合金; 骨誘導; Mg イオン; 細胞培養; ALP; Ti-Mg 合金; 骨形成; マグネシウム合金; Mgイオン; 血管内費細胞; チタン; マグネシウム; インプラント; 生体材料

In this research program, we tried to develop the titanium alloy equipped with an osteoinductive property derived from sustained delivery of Mg ions. Although the Ti-Mg solid solution with the sustained delivery of Mg ions could not be obtained, under the conditions of Mg ions, the amount of DNAs and cell growth were as same as those of controls, and the ALP activity values significantly increased. Since the vascular proliferation was observed in the vascular endothelial cells and the lumen formation, we concluded that it is preferable to develop the Ti-Mg solid solution as anew functional material.

在本研究项目中，我们试图开发一种钛合金，该合金具有通过持续输送镁离子而获得的骨诱导性能。虽然不能获得持续输送镁离子的钛镁固溶体，但在镁离子存在的条件下，DNA的数量和细胞的生长与对照组相同，碱性磷酸酶的活性值显著增加。由于在血管内皮细胞中观察到血管的增殖和管腔的形成，我们认为开发钛镁固溶体作为一种新的功能材料是可取的。