Development of the bioactive titanium alloy equipped with an osteoinductive property

在本研究计划中，我们试图开发具有骨诱导性能的钛合金，该性能来自镁离子的持续输送。虽然没有得到镁离子缓释的钛镁固溶体，但在镁离子条件下，细胞DNA含量和细胞生长与对照组相同，ALP活性值显著升高。由于在血管内皮细胞中观察到血管增殖和管腔形成，我们得出结论，优选开发Ti-Mg固溶体作为新的功能材料。

In this research program, we tried to develop the titanium alloy equipped with an osteoinductive property derived from sustained delivery of Mg ions. Although the Ti-Mg solid solution with the sustained delivery of Mg ions could not be obtained, under the conditions of Mg ions, the amount of DNAs and cell growth were as same as those of controls, and the ALP activity values significantly increased. Since the vascular proliferation was observed in the vascular endothelial cells and the lumen formation, we concluded that it is preferable to develop the Ti-Mg solid solution as anew functional material.