Regulation of autophagy by microproteins and RNA modifications (F05*)

通过微生物蛋白和 RNA 修饰调节自噬 (F05*)

• 批准号: 533862127
• 金额: --
• 依托单位: Institut für Pharmazeutische Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/533862127?language=en
• 关键词: Regulation; autophagy; microproteins; RNA; modifications

Our preliminary data revealed several microproteins that are significantly up- or downregulated upon autophagy disruption or infection with Acinetobacter baumannii. Building up on this observation, this project seeks to characterize the underlying molecular mechanisms that regulate the interplay between microproteins and autophagy and to assess the modulation of autophagy-related microproteins upon infection. One focus will be on tRNA modifications as key modulator of microprotein expression in the context of xenophagy.

我们的初步数据揭示了几种微蛋白在自噬破坏或感染鲍曼不动杆菌后显著上调或下调。基于这一观察，该项目旨在表征调节微蛋白和自噬之间相互作用的潜在分子机制，并评估感染后自噬相关微蛋白的调节。其中一个重点将是tRNA修饰作为关键的调节剂的微蛋白表达的背景下，异食。