Full automatic high quality control system of brain hypothermia treatment

脑低温治疗全自动高质量控制系统

• 批准号: 16300170
• 负责人: WAKAMATSU Hidetoshi
• 金额: $ 4.03万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300170/
• 关键词: Brain hypothermia; Automatic administration; Adaptive control; Fuzzy control; Administration of brain temperature; Respiration; Surface water-cooling; Surface air-cooling; ファジィ制御; 水冷式表明冷却; 集中治療・管理; 脳圧制御; 生理状態測定; 冷却媒体; 冷却装置; 脳温制御

Automatic control systems of brain tissue temperature were experimentally studied for the brain hypothermia treatment. The water-cooling and warming system was designed and constructed according to the heat exchange dynamic characteristics. In order to realize human friendly control mechanism, an automatic temperature regulation systems were constructed by adaptive and fuzzy algorithm for possible environmental and characteristic change of patients. The brain temperature was successfully realized to follow up automatically the desired temperature course prescribed by physicians. Thus, the model reference control of the brain temperature based on water-cooling blankets was verified for the clinical application to brain hypothermia treatment through the various kinds of experiments using a human thermal model. For the effectiveness and convenience of emergency or in ambulance, air-cooling system was developed based on the its simulation in consequence to water-cooling system, including the study of optimal cranial pressure control on the injury or ischemic damage of brain and of the automatic respiratory control by adaptive pole placement method.

对脑组织温度自动控制系统进行了实验研究。根据换热动态特性，设计并搭建了水冷却和水加热系统。为了实现人性化的控制机制，针对患者可能出现的环境和特征变化，采用自适应和模糊算法构建了自动温度调节系统。成功地实现了脑温自动跟踪医生指定的期望温度过程。因此，通过使用人体热模型的各种实验，验证了基于水冷毯的脑温度的模型参考控制对于脑低温治疗的临床应用。为了在紧急情况下或在救护车上使用时的有效性和方便性，在对水冷系统进行仿真的基础上，开发了风冷系统，包括对脑损伤或缺血性损伤的最佳颅压控制和自适应极点配置方法的自动呼吸控制的研究。