Development of instantaneous laser hemostasis on sheath removal hole after catheter intervention

导管介入术后拔鞘孔瞬时激光止血技术的研究进展

• 批准号: 16300177
• 负责人: ARAI Tsunenori
• 金额: $ 9.54万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300177/
• 关键词: laser welding; sheath removal hole; diode laser; tissue characterization; backscattering light

Hemostasis method of sheath removal hole after catheter intervention should be improved to reduce patient inconvenience and doctor' s labor. I have had a idea to apply laser tissue welding technique to make above mentioned problem..2004 financial yearI developed experimental system with porcine carotid artery pressurized by saline to study many parameters of laser tissue welding along the laser irradiation time. Diode laser (wavelength:800nm approxi.) light was irradiated through an optical fiber traveled by automatic-stage with constant speed to the artery model stained by indocyanine green. Pressure and temperature in the model were measured by a digital recorder. The best sealing was obtained when the laser power was 0.75W with 50um/s in the traveling speed. A personal computer was used as data processing and documentation.2005 financial yearI developed experimental system with arterial pressure even when leak hole presented in the artery model. Thin angioscope was fabricated to observe intraluminal view during the sealing procedure. The sheath removal hole was sealed up to 97% of its area by adventitia welding. The temperature measurement and fluorescence measurement by the fluorospectrophotometer revealed that the mechanism of this sheath hole closure may be collagen fiber welding by laser heating.2006 financial yearTo attain stable sealing, I developed new feedback control system using light measurement at the fiber tip to arrange laser irradiation power. I developed a novel fiber tip geometry to diffuse irradiation light to the sheath hole. I conclude that bleaching measurement of indocyanine green which is correlated with received laser power can not be used for temperature monitoring of the fiber tip due to the lack accuracy

导管介入后鞘管取出孔的止血方法应改进，以减少患者不便和医生劳动。我有一个想法，应用激光组织焊接技术，使上述问题。2004财政年度我开发了实验系统，用盐水加压猪颈动脉，研究激光组织焊接的许多参数沿着激光照射时间。半导体激光器（波长：约800 nm）光通过由自动载物台以恒定速度行进的光纤照射到被吲哚菁绿色染色的动脉模型。模型中的压力和温度由数字记录仪测量。当激光功率为0.75W，激光行进速度为50 μ m/s时，封接效果最好。使用个人计算机进行数据处理和记录。2005财政年度我开发了实验系统，即使在动脉模型中出现泄漏孔时也能测量动脉压。制作了薄血管镜，用于在封合过程中观察管腔内视图。通过外膜焊接将鞘管取出孔密封至其面积的97%。温度测量和荧光测量的荧光分光光度计显示，该鞘孔封闭的机制可能是胶原纤维焊接激光加热。2006财政年度为了实现稳定的密封，我开发了新的反馈控制系统，使用光测量在光纤尖端安排激光照射功率。我开发了一种新颖的光纤尖端几何形状，以将照射光扩散到鞘孔。我的结论是，吲哚菁绿色的漂白测量与接收的激光功率相关，由于缺乏准确性，不能用于光纤尖端的温度监测