Development of instantaneous laser hemostasis on sheath removal hole after catheter intervention

应改进导管介入后脱鞘孔止血方法，减少患者的不便和医生的劳动。我有一个想法，应用激光组织焊接技术来解决上述问题。2004财政年度研制了猪颈动脉生理盐水加压实验系统，研究激光组织焊接的诸多参数随激光照射时间的变化。将波长约为800nm的二极管激光通过自动等速行进的光纤照射到吲哚菁绿染色的动脉模型上。模型内的压力和温度由数字记录仪测量。当激光功率为0.75W，行进速度为50um/s时，密封效果最佳。一台个人电脑被用作数据处理和文件编制。2005财政年度，我开发了动脉压实验系统，即使在动脉模型中出现漏孔。制作薄血管镜观察封闭过程中的腔内情况。通过外膜焊接，将护套去除孔的面积密封了97%。荧光分光光度计的温度测量和荧光测量表明，这种护套闭合的机制可能是激光加热焊接胶原纤维。为了达到稳定的密封，我开发了新的反馈控制系统，利用光纤尖端的光测量来安排激光照射功率。我开发了一种新的光纤尖端几何形状，以扩散照射光到鞘孔。本文认为，与接收激光功率相关的吲哚菁绿漂白测量由于精度不足，不能用于光纤尖端的温度监测

Hemostasis method of sheath removal hole after catheter intervention should be improved to reduce patient inconvenience and doctor' s labor. I have had a idea to apply laser tissue welding technique to make above mentioned problem..2004 financial yearI developed experimental system with porcine carotid artery pressurized by saline to study many parameters of laser tissue welding along the laser irradiation time. Diode laser (wavelength:800nm approxi.) light was irradiated through an optical fiber traveled by automatic-stage with constant speed to the artery model stained by indocyanine green. Pressure and temperature in the model were measured by a digital recorder. The best sealing was obtained when the laser power was 0.75W with 50um/s in the traveling speed. A personal computer was used as data processing and documentation.2005 financial yearI developed experimental system with arterial pressure even when leak hole presented in the artery model. Thin angioscope was fabricated to observe intraluminal view during the sealing procedure. The sheath removal hole was sealed up to 97% of its area by adventitia welding. The temperature measurement and fluorescence measurement by the fluorospectrophotometer revealed that the mechanism of this sheath hole closure may be collagen fiber welding by laser heating.2006 financial yearTo attain stable sealing, I developed new feedback control system using light measurement at the fiber tip to arrange laser irradiation power. I developed a novel fiber tip geometry to diffuse irradiation light to the sheath hole. I conclude that bleaching measurement of indocyanine green which is correlated with received laser power can not be used for temperature monitoring of the fiber tip due to the lack accuracy