Effects of active muscles on cardiovascular and hormonal responses during exercise and training.

我们的目的是研究动脉压力感受性反射（ABR）和肌肉代谢反射之间的相互作用，以及动脉压力感受性反射和心肺压力感受性反射之间的相互作用，每一个都与肌肉交感神经活动（MSNA）和血压的调节有关，并通过检查颈动脉压力感受性反射引起的肌肉交感神经活动（MSNA）变化的时间过程，结果表明：1）ABR功能的调节是等长运动过程中血压和MSNA进行性升高的机制之一; 2）在肌肉代谢反射的激活过程中，在人类中，MAP和股动脉血管阻力之间的动态关系的调节反映了内在血管调节机制和交感神经血管调节之间的复杂相互作用。3）在直立状态期间，表明随着直立应力的增加，对MSNA的ABR控制被逐渐调节，从而在与直立性晕厥相关的严重低血压之前的时期内其敏感性显著降低。

We aimed to investigate the interactions between arterial baroreflex (ABR) and muscle metabo-reflex, and between arterial baroreflex and cardiopulmonary baroreflex, each with respect to the regulation of muscle sympathetic nervous activity (MSNA) and blood pressure, and by examining the time course of the carotid-baroreflex-induced alterations in muscle sympathetic nerve activity (MSNA), mean arterial blood pressure (MAP) and heart rate (HR) in humans.1) It was suggested that the modulation of ABR function is one of the mechanisms underlying the progressive increase in blood pressure and MSNA during the course of isometric exercise.2) During activation of the muscle metaboreflex, it was suggested that, in humans, modulation of the dynamic relationship between MAP and femoral arterial vascular resistance reflects complex interactions between intrinsic vascular regulatory mechanisms and sympathetic vascular regulation.3) During orthostatic condition, it was suggested that ABR control over MSNA is progressively modulated as orthostatic stress increases, so that its sensitivity is substantially reduced during the period immediately preceding the severe hypotension associated with orthostatic syncope.