Holographic femtosecond laser processing for biological tissue

生物组织全息飞秒激光加工

• 批准号: 16360035
• 负责人: HAYASAKI Yoshio
• 金额: $ 8.64万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16360035/
• 关键词: Information photonics; Femtosecond laser processing; Spatial light modulator; Information biological media; Parallel processing; Holography; Optical computing; Three-dimensional optical devices; 生体メディア; 並列光加工; ホログラフィック加工; ビジュアルフィードバック; 計算機ホログラ

Femtosecond laser processing (FsLP) provides high spatial resolution and causes reduced thermal destruction to a target as a result of the ultra-short interaction time between the laser pulse and the material. Furthermore, when a femtosecond laser pulse is tightly focused in a transparent material, a void and a refractive index change are formed inside. To fabricate an optical device, a huge number of processing points is required. Therefore, the processing speed must be sufficiently high to enable the desired throughput. We have demonstrated a holographic FLP (H-FsLP) with parallel, arbitrary, and variable patterning features, which were achieved by using a liquid crystal spatial light modulator (LCSLM) displaying a computer-generated hologram (CGH). In such parallel laser processing methods, the uniformity of the diffraction peaks is presently a key issue to be resolved.We have demonstrated the H-FsLP with a multiplexed-phase Fresnel lenses (MPFL), which were optimized by regulating the center phase and the diameter of the constituent PFLs while taking account of the LCSLM properties and the spatial profile of the irradiated laser pulse. By the optimization, the uniformity of the diffraction peaks in optical system was improved to the maximum value of 95%. To realize further improvement of the uniformity, an optimization method with an optical estimation was applied. The uniformity was improved to the maximum value of 98%. A f-FsLP with a target tracking feature was developed for the processing of biological tissues. The block matching method based on a sum-of-squared-difference metric was used to measure the transverse movement of the target. Surface position was detected with an astigmatic sensor to measure the axial movement. The maximum tracking speeds of the target in the transverse and axial directions were 255 μm/s and 125 μm/s, respectively.

飞秒激光处理(FsLP)提供了高空间分辨率，并由于激光脉冲与材料之间的超短相互作用时间而减少了对目标的热破坏。此外，当飞秒激光脉冲在透明材料中紧密聚焦时，内部会形成空洞和折射率变化。要制造光学器件，需要大量的加工点。因此，处理速度必须足够高，才能实现所需的吞吐量。我们展示了一种具有平行、任意和可变图案化特征的全息FLP(H-FsLP)，它是通过显示计算全息图(CGH)的液晶空间光调制器(LCSLM)实现的。在这种并行激光加工方法中，衍射峰的均匀性是目前需要解决的一个关键问题。我们展示了具有多相位菲涅耳透镜(MPFL)的H-FsLP，它是通过调节组成PFL的中心相位和直径来优化的，同时考虑到LCSLM的性质和被照射激光脉冲的空间轮廓。通过优化，使光学系统中衍射峰的均匀性提高到最大值95%。为了进一步提高均匀性，采用了一种光学估计的优化方法。均匀度提高到最大值，达到98%。开发了一种用于生物组织处理的具有目标跟踪功能的f-FsLP。采用基于差平方和度量的块匹配法测量目标的横向运动。用散光传感器检测表面位置以测量轴向运动。目标在横向和轴向的最大跟踪速度分别为255μm/S和125μm/S。

项目成果

Secure information display with limited viewing zone by use of multi-color visual cryptography.

• DOI: 10.1364/opex.12.001258
• 发表时间: 2004-04
• 期刊: Optics express
• 影响因子: 3.8
• 作者: Hirotsugu Yamamoto;Y. Hayasaki;N. Nishida

Secure information display with two limited viewing zones by use of two decoding masks based on visual secret sharing scheme

基于视觉秘密共享方案，使用两个解码掩模，以两个有限观看区域安全地显示信息

• 发表时间: 2005
• 期刊: Japanese Journal of Applied Physics Vol.44, No.4A
• 作者: S. Kobayashi;et. al.;H.Yamamoto
• 通讯作者: H.Yamamoto

Processing structures on human fingernail surface by a focused near-infrared femtosecond laser pulse

通过聚焦近红外飞秒激光脉冲处理人类指甲表面的结构

• 发表时间: 2004
• 期刊: Japanese Journal of Applied Physics 43・12
• 作者: M. Mimura;et. al.;H.Yamamoto;Y.Hayasaki
• 通讯作者: Y.Hayasaki

Method for reducing debris and thermal destruction in femtosecond laser processing by applying transparent coating

• DOI: 10.1007/s00339-005-3422-y
• 发表时间: 2006-02
• 期刊: Applied Physics A
• 作者: D. Kawamura;A. Takita;Y. Hayasaki;N. Nishida

Bump formation on glass surface with a transparent coating using femtosecond laser processing

使用飞秒激光加工在带有透明涂层的玻璃表面形成凸块

• 发表时间: 2006
• 期刊: Aapplied Physics A 85・1
• 作者: Satoru Fujiyoshi;Taka-aki Ishibashi;Hiroshi Onishi;Satoshi Hasegawa;Daiki Kawamura
• 通讯作者: Daiki Kawamura