Development of high sensitivity, light-weight portable gamma camera based on innovative fundamentals for nuclear medicine examinations

基于核医学检查创新原理开发高灵敏度、轻型便携式伽马相机

• 批准号: 16390343
• 负责人: KUBO Atushi
• 金额: $ 9.15万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390343/
• 关键词: gamma-ray; Compton Camera; nuclear medicine; isotope; 放射線; コンプトン効果; 可搬型ガンマカメラ; 超高感度; 超軽量; コンプトン散乱; 検出器

The Compton Camera which can directly detect the incident direction of gamma-ray does not need the collimator in principle. This camera is very efficient and high sensitive because it can utilize the information of gamma-ray from various directions.We applied Compton effects for nuclear medicine field and developed a new-type gamma camera which omits the shielding around the collimator and detector. We have realized both full ray-tracing and the background rejection for MeV and sub-MeV gamma-ray imaging by detecting the direction of the scatted electron in Compton process.The Compton camera is consisted of two detectors. Incident gamma-ray is scattered in the first (scatter) detector by Compton scattering. This detector takes the recoil electron energy. Our system utilizes a gas chamber as the first detector and the track of the recoil electron was detected with a flat detector placed on the edge of the gas chamber. The scattered gamma-ray is stopped in the second (absorb) detector. The second detector takes the energy and position of scattered gamma-ray. Using above energy and position information, the Compton gamma-ray camera is able to reconstruct the incident gamma-ray direction as cylindrical direction. What is important is that this system does not need the collimator. It enables the wide energy dynamic range and wide FOV.

康普顿照相机原理上不需要准直器，可以直接探测γ射线的入射方向。我们将康普顿效应应用于核医学领域，研制了一种新型的γ射线照相机，它省去了准直器和探测器周围的屏蔽。通过对康普顿散射过程中散射电子方向的探测，实现了MeV和亚MeV γ射线成像的全射线追踪和背景抑制。入射伽马射线在第一（散射）探测器中通过康普顿散射而散射。这个探测器吸收反冲电子的能量。我们的系统利用气体室作为第一个探测器和反冲电子的轨道被检测与放置在气体室的边缘的平面探测器。散射的伽马射线在第二个（吸收）探测器中停止。第二探测器获取散射伽马射线的能量和位置。使用上述能量和位置信息，康普顿伽马射线相机能够将入射伽马射线方向重建为圆柱方向。重要的是，该系统不需要准直器。它实现了宽能量动态范围和宽FOV。

项目成果

Repair of potentially lethal damage in normal cells and ataxia telangiectasia cells; Consideration of non-homologous end-joining

• DOI: 10.1269/jrr.0642
• 发表时间: 2007-01-01
• 期刊: JOURNAL OF RADIATION RESEARCH
• 影响因子: 2
• 作者: Kan'o, Momoe;Kawata, Tetsuya;Kubo, Atsushi
• 通讯作者: Kubo, Atsushi

Development of an advanced Compton camera with gaseous TPC and scintillator

• DOI: 10.1016/j.nima.2005.03.050
• 发表时间: 2005-07-01
• 期刊: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
• 影响因子: 1.4
• 作者: Takada, A;Hattori, K;Tanimori, T
• 通讯作者: Tanimori, T

Compton gamma-ray imaging detector with electron tracking

具有电子跟踪功能的康普顿伽马射线成像探测器

• 发表时间: 2004
• 期刊: Nuclear Instruments and Methods in Physics Research A 525
• 作者: R.Orito;T.Tanimori 他
• 通讯作者: T.Tanimori 他

Value of CT thallium-201 SPECT fusion imaging over SPECT alone for detection and localization of nasopharyngeal and maxillary cancers.

CT 铊-201 SPECT 融合成像相对于单独 SPECT 的鼻咽癌和上颌癌检测和定位的价值。

• 发表时间: 2006
• 期刊: AJR Am J Roentgenol. 187(3)
• 作者: Nakahara T;Shigematsu N;Fujii M;Kunieda E;Suzuki T;Kubo;A. et al.
• 通讯作者: A. et al.

Rotational and translational reproducibility of newly developed Leksell frame-based relocatable fixation system Radial Med. 24(7) : 503-10. 2006

新开发的基于 Leksell 框架的可重定位固定系统 Radial Med 的旋转和平移再现性。

• 发表时间: 2006
• 期刊: Radial Med 24(7)
• 作者: Kunieda E;Deloar HM;Kitamura M;Kawaguchi 0;Shiba H;Takeda A;Kawase T;Seki S;Shigematsu N;Kubo A
• 通讯作者: Kubo A