Development of small diameter artificial blood vessel for remodeling of elastomeric-artery

本研究的目的是开发一种新型的使用弹性蛋白基质的小口径人造血管，用于治疗血管疾病。2004年(第一年)，研制了细胞培养皿和动态细胞培养弹力片。并于2005年(第二年)研究了这些材料与血壁细胞的粘附性。2006年(最后一年)对弹性蛋白基质上的平滑肌细胞的分化特性进行了研究，在弹力片上对平滑肌细胞、内分泌细胞和成纤维细胞进行了评价，结果表明弹性蛋白材料促进了平滑肌细胞的分化，抑制了细胞的增殖。在本研究中，我们得出结论：弹性蛋白基质是在动态细胞培养条件下重建弹力动脉的合适材料。

The aims of this study are the development of a novel small diameter artificial blood vessel using elastin matrix for treatment of vessel disease. In 2004 (first year), the cell cultured dish and elastic-sheet for the dynamic cell culture were prepared. And in 2005 (second year), the adhesion properties was researched as the reactions of blood wall-cells for these materials. In 2006 (final year), the differentiation property of smooth muscle cells on the elastin-matrix was researched.The smooth muscle cells, endocrinal cells and fibroblast cells were evaluated on the elastic-sheets, in results, the important information was taken as the acceleration of differentiation of smooth muscle cells and the inhibition of proliferation by elastin materials. In this study, we concluded that elastin matrix was the suitable material for remodeling of elastomeric-artery under dynamic cell culture conditions.