New PET diagnosis of adenosine receptors in the brain, heart and skeletal muscle

大脑、心脏和骨骼肌腺苷受体的新 PET 诊断

• 批准号: 16390348
• 负责人: ISHIWATA Kiichi
• 金额: $ 9.09万
• 依托单位: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390348/
• 关键词: Adenosine receptor; PET; [^<11>C]MPDX; [^<11>C]TMSX; Brain; Heart; Muscle; アルツハイマー病; パーキンソン病; てんかん; 加齢; P糖タンパク質

The purpose of the present study is to propose new PET diagnosis using [^<11>C]MPDX and [^<11>C]TMSX for imaging adenosine A_1 and A_<2A> receptors, respectively, in the brain, heart and muscle1. By applying [^<11>C]MPDX-PET and [^<11>C]TMSX-PET to normal subjects, A_1 and A_<2A> receptors, respectively, was quantitatively measured by compartment and graphical analyses using dynamic PET scan and serial arterial blood data.2. To avoiding invasive arterial blood sampling, a non-invasive quantitative method EPICA was successfully applied to both[^<11>C]MPDX-and [^<11>C]TMSX-PET.3. In the patients with Alzheimer's disease, a significantly decreased binding of [^<11>C]MPDX was observed in the bilateral medial temporal cortex and left temporo-parietal cortex. The decreased binding pattern of [^<11>C]MPDX was different from hypometabolism. In the patients with temporal lobe epilepsy, binding of [^<11>C]MPDX was significantly decreased in the mesial temporal lobe of focus side outside the hippocampus, but increased in the frontal cortex of focus side.4. In the patients with Parkinson's disease whose the left-side dopamine transporter was more decreased than the right side one, the dopamine D_2 receptors bindings was increased bilaterally, while the adenosine A_<2A> receptor was decreased on the left side.5. Following animal experiments, adenosine A_<2A> receptors in the heart and muscle were quantitatively evaluated in normal subjects. Adenosine A_<2A> receptor binding in the cardiac and skeletal muscles was greater in the endurance-trained men than in the untrained men.We concluded that [^<11>C]MPDX-PET and [^<11>C]TMSX-PET provides diagnostic tools of the physiological and pathological states of various diseases in term of adenosine receptors.

本研究的目的是使用[^<11> c] mpdx和[^<11> c] TMSX提出新的PET诊断，以成像腺苷A_1和A_ <2A>受体，在大脑，心脏和肌肉中。通过使用动态PET扫描和串行动脉血数据，分别将[^<11> c] mpdx-pet和[^<11> C] TMSX-PET应用于正常受试者A_1和A_1和A_ <2A>受体。为了避免侵入性动脉血液采样，非侵入性定量方法Epica成功地应用于[^<11> c] mpdx- and [^<11> c] tmsx-pet.3。在阿尔茨海默氏病的患者中，在双侧内侧颞皮层和左颞顶皮层中观察到[^<11> C] MPDX的结合显着降低。 [^<11> c] MPDX的结合模式降低与低代谢不同。在颞叶癫痫的患者中，在海马外部的聚焦一侧的近内颞叶中，[^<11> c] mpdx的结合显着降低，但在聚焦侧面的额叶皮层中增加。4。在帕金森氏病的患者中，左侧多巴胺转运蛋白比右侧的患者减少了，多巴胺D_2受体结合的结合是双侧增加的，而腺苷A_ <2A>受体在左侧降低。5。在动物实验之后，在正常受试者中对心脏和肌肉中的腺苷A_ <2A>受体进行了定量评估。在受耐力训练的男性中，心脏和骨骼肌中的腺苷A_ <2A>比未经训练的男性更大。我们的结论是，[^<11> c] mpdx-pet和[^<11> c] tmsx-pet提供了各种疾病的诊断症状受体的生理和病理学态诊断。

项目成果

Potential of [^<11>C]TMSX for evaluation of adenosine A_<2A> receptors in the skeletal muscle by positron emission tomography.

[^ 11 C]TMSX通过正电子发射断层扫描评估骨骼肌中腺苷A_ 2A 受体的潜力。

• 发表时间: 2004
• 期刊: Nucl.Med.Biol 31(7)
• 作者: Ishiwata K;Mizuno M;Kimura Y;Kawamura K;Oda K;Sasaki T;Nakamura Y;Muraoka;Ishii K
• 通讯作者: Ishii K

Quantitative analysis of adenosine A, receptors in human brain using positron emission tomography and [1-methyl-^<11>C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine.

使用正电子发射断层扫描和[1-甲基-^ 11 C]8-二环丙基甲基-1-甲基-3-丙基黄嘌呤对人脑中的腺苷A受体进行定量分析。

• 发表时间: 2004
• 期刊: Nucl.Med.Biol. 31・8
• 作者: Kimura Y;Ishii K;Fukumitsu N;Oda K;Sasaki T;Kawamura K;Ishiwata K.
• 通讯作者: Ishiwata K.

Distribution of adenosine A_2_A receptors in normal human brain by 〔^<11>C〕TMSX PET.

通过[^ 11 C]TMSX PET观察正常人脑中腺苷A_2_A受体的分布。

• 期刊: Synapse (in press)
• 作者: Mishina M;Ishiwata K;Kimura Y;Naganawa M;Oda K;Kobayashi S;Kitamura S;Katayama;Y;Ishii K.
• 通讯作者: Ishii K.

Greater adenosine A_<2A> receptor densities in cardiac and skeletal muscle in endurance trained men : a [^<11>]TMSX PET study

接受过耐力训练的男性心肌和骨骼肌中的腺苷 A_<2A> 受体密度更高：[^<11>]TMSX PET 研究

• 发表时间: 2005
• 期刊: Nuclear Medicine and Biology 32・8
• 作者: Mizuno M;Kimura K;Tokizawa K;Ishii K;Oda K;Sasaki T;Nakamura Y;Muraoka I;Ishiwata K.
• 通讯作者: Ishiwata K.

In vivo evaluation of P-glycoprotein modulation of eight PET radioligands used clinically.

临床使用的八种 PET 放射性配体 P-糖蛋白调节的体内评估。

• 发表时间: 2007
• 期刊: J. Nucl. Med. 48・1
• 作者: Ishiwata K;Kawamura K;Yanai K;Hendrikse NH
• 通讯作者: Hendrikse NH