Analysis of brainstem neural networks related to laryngeal multifunctional activities

与喉多功能活动相关的脑干神经网络分析

基本信息

批准号：
16390485
负责人：
SHIMOYAMA Ichiro
金额：
$ 8万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390485/
关键词：
larynx brainstem respiratory neuron

项目摘要

Respiration, as well as vocalization and upper airway defensive reflexes such as swallowing and coughing, is one of the important laryngeal functions. To determine the synaptic source of the respiratory-related activity of laryngeal motoneurons, spike-triggered averaging of the membrane potentials of laryngeal motoneurons was conducted using spikes of respiratory neurons located between the Botzinger complex and the rostral ventral respiratory group as triggers in decerebrate, paralyzed cats. We identified one excitatory and two inhibitory sources for inspiratory laryngeal motoneurons, and two inhibitory sources for expiratory laryngeal motoneurons. In inspiratory laryngeal motoneurons, monosynaptic excitatory postsynaptic potentials were evoked by spikes of inspiratory neurons with augmenting firing patterns, and monosynaptic inhibitory postsynaptic potentials (IPSPs) were evoked by spikes of expiratory neurons with decrementing firing patterns and by spikes of inspiratory neurons with decrementing firing patterns. In expiratory laryngeal motoneurons, monosynaptic IPSPs were evoked by spikes of inspiratory neurons with decrementing firing patterns and by spikes of expiratory neurons with augmenting firing patterns. We conclude that various synaptic inputs from respiratory neurons contribute to shaping the respiratory-related trajectory of membrane potential of laryngeal motoneurons.

呼吸，发声和上呼吸道防御反射（例如吞咽和咳嗽）是重要的喉功能之一。为了确定喉部运动神经元与呼吸道相关活性的突触来源，使用位于鲍辛格复合物与骨膜腹膜腹膜腹膜术组之间的呼吸神经元的尖峰进行了刺激性的喉部膜电位的平均。我们确定了一种灵感喉运动神经元的兴奋性和两种抑制作用，以及两个用于呼气的喉运动神经元的抑制源。在吸气性的喉部运动神经元中，单突触兴奋性突触后潜在的突触后，通过增强发射模式的吸气神经元的尖峰引起了单次突触的突触后潜能（IPSP）的尖峰，并通过降低了模式的跨度和模式的刺激措施引起了呼吸神经元的峰值，并逐渐消失。在呼气的喉运动神经元中，单突触IPSP被吸气模式下降的灵感神经元的尖峰和呼气性神经元的尖峰引起，并具有增强的射击模式。我们得出的结论是，来自呼吸神经元的各种突触输入有助于塑造喉运动神经元的膜相关轨迹。