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Relationship between impulsivity and lipid metabolism, and immune function among the young patients with eating disorders, depression and social anxiety disorder

青年进食障碍、抑郁症、社交焦虑症患者冲动性与脂质代谢及免疫功能的关系

基本信息

批准号：
16591153
负责人：
NEGATA Toshihiko
金额：
$ 2.43万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

项目摘要

Previous our studies suggested the possibilities that psychological factors rather than the abnormal eating behaviors contribute immunological functions. Alternatively, other factors such adipocytokines (adiponectin, leptin, resistin) or brain-derived neurotrophic factor (BDNF) might contribute anxiety or depressive mood in eating disorder patients. In this current study, we investigates the relationship between abnormal eating behaviors, psychological states (general anxiety and depressive mood), immunological functions, adipocytokines and BDNF in the patients with bulimia nervosa cross-sectionally as well longitudinally.Subjects consisted of 16 female patients with bulimia nervosa and 9 controls. Eight patients with bulimia nervosa were longitudinally studied. All were given written informed.There were no significant differences in CD4/CD8 ratio of lymphocyte, stimulation index of lymphocyte proliferative responses, tumor necrosis factor, adiponectin, leptin soluble receptor, and resistin between bulimia nervosa and controls. However, patients with bulimia nervosa showed significantly lower leptin and BDNF than controls. In addition, BDNF was significantly (inversely) related with frequencies of binge and vomiting. In longitudinal study, low BDNF recovered according to improvement of abnormal eating behaviors and psychological states.Contrast with hypotheses, this study suggested that BDNF might be influenced by negative psychological states and abnormal eating behaviors. Alternatively, BDNF rather than the adipocytokines or cytokines negatively influenced psychological states. To resolve these mechanisms, longitudinal study in larger sample is needed.

我们之前的研究表明，可能是心理因素而不是异常饮食行为影响了免疫功能。或者，其他因素，如脂肪细胞因子(脂联素、瘦素、抵抗素)或脑源性神经营养因子(BDNF)可能会导致进食障碍患者的焦虑或抑郁情绪。本研究从横向和纵向两个方面探讨了神经性贪食症患者的饮食异常行为、心理状态(一般焦虑和抑郁情绪)、免疫功能、脂肪细胞因子和脑源性神经营养因子之间的关系。对8例神经性贪食症患者进行了纵向研究。神经性贪食症患者外周血中淋巴细胞的CD_4/CD_8比值、淋巴细胞增殖反应刺激指数、肿瘤坏死因子、脂联素、瘦素可溶性受体、抵抗素与对照组比较差异无统计学意义。然而，神经性贪食症患者的瘦素和脑源性神经营养因子水平明显低于对照组。此外，脑源性神经营养因子与暴饮暴食和呕吐次数呈显著负相关。在纵向研究中，低BDNF随着异常饮食行为和心理状态的改善而恢复，与假设对照，本研究提示BDNF可能受到消极心理状态和异常饮食行为的影响。或者，BDNF而不是脂肪细胞因子或细胞因子对心理状态产生负面影响。要解决这些机制，需要在更大样本中进行纵向研究。